Evidence map›Paper›PMID 39864653›Full record

ArticleEnvironmental pollution (Barking, Essex : 1987)2025

Oxidative gaseous air pollutant exposure interacts with PNPLA3-I148M genotype to influence liver fat fraction and multi-omics profiles in young adults.

William B Patterson, Nathan D Young, Elizabeth A Holzhausen, Frederick Lurmann, Donghai Liang, Douglas I Walker, Dean P Jones, Jiawen Liao, Zhanghua Chen, David V Conti and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental pollution (Barking, Essex : 1987), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

William B PattersonDepartment of Biomedical Informatics, University of Colorado School of Medicine, Aurora, CO, USA.
Nathan D YoungDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Elizabeth A HolzhausenDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Frederick LurmannSonoma Technology, Inc., Petaluma, CA, USA.
Donghai LiangGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Douglas I WalkerGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Dean P JonesClinical Biomarkers Laboratory, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University, Atlanta, GA, USA.
Jiawen LiaoDepartment of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA.
Zhanghua ChenDepartment of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA.
David V ContiDepartment of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA.
Lida ChatziDepartment of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA.
Jesse A GoodrichDepartment of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA.
Tanya L AldereteDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: taldere1@jhu.edu.

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
Urban Air Pollution and Children's Respiratory HealthP01ES011627 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AVOL, EDWARD · 2002 to 2011
$30.2M
Southern California Center for Chronic Health Disparities in Latino Children and Families.P50MD017344 · NIMHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI COHEN, DEBORAH A · 2021 to 2025
$27.8M
Southern California Children's Environmental Health Center (SC-CEHC)P01ES022845 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HRICKO, ANDREA M · 2013 to 2018
$4.0M
Environmental Chemical Exposures and Longitudinal Changes of Glucose Metabolism, Insulin Sensitivity and B Cell Function in YouthR01ES029944 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHATZI, VAIA LIDA · 2019 to 2023
$3.1M
Longitudinal integration of environmental exposures, omics, and childhood NAFLD (LEON) StudyU01HG013288 · NHGRI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AUNG, TUN (MAX) M, CHATZI, VAIA LIDA · 2023 to 2025
$2.4M
Metabolomic Signatures Linking Air Pollution, Obesity and DiabetesR00ES027870 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, ZHANGHUA · 2019 to 2021
$747k
Near-Roadway and Ambient Air Pollution Exposure and the Gut Microbiome: Implications for Obesity and Insulin Resistance in AdolescenceR00ES027853 · NIEHS · UNIVERSITY OF COLORADO · PI ALDERETE, TANYA LYNN · 2018 to 2020
$721k
Near-Roadway and Ambient Air Pollution Exposure and the Gut Microbiome: Implications for Obesity and Insulin Resistance in AdolescenceK99ES027853 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ALDERETE, TANYA LYNN · 2017 to 2018
$202k
Metabolomic Signatures Linking Air Pollution, Obesity and DiabetesK99ES027870 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, ZHANGHUA · 2018 to 2019
$176k
Exposure to Ambient Air Pollutants, Circulating microRNAs, and Hepatic Fat Fraction Among Young AdultsF31DK134198 · NIDDK · UNIVERSITY OF COLORADO · PI PATTERSON, WILLIAM BROOKS · 2022 to 2023
$80k
NHGRI NIH HHS U01 HG013288NIDDK NIH HHS F31 DK134198NIEHS NIH HHS K99 ES027853NIEHS NIH HHS K99 ES027870NIEHS NIH HHS P01 ES011627NIEHS NIH HHS P01 ES022845NIEHS NIH HHS P30 ES007048NIEHS NIH HHS R00 ES027853NIEHS NIH HHS R00 ES027870NIEHS NIH HHS R01 ES029944NIMHD NIH HHS P50 MD017344
6 · The paper itself

Abstract

PNPLA3-I148M genotype is the strongest predictive single-nucleotide polymorphism for liver fat. We examine whether PNPLA3-I148M modifies associations between oxidative gaseous air pollutant exposure (O

Indexed as

Air PollutantsEnvironmental ExposureLipaseMembrane ProteinsAcyltransferasesAdolescentAir PollutionFemaleGenotypeHumansLiverMaleMultiomicsPhospholipases A2, Calcium-IndependentPolymorphism, Single NucleotideYoung AdultAcyltransferasesAir PollutantsLipaseMembrane ProteinsPhospholipases A2, Calcium-IndependentPNPLA3 protein, humanAir pollutionEnvironmental epidemiologyEpidemiologyLiver fatMetabolomicsOzonePNPLA3

Identifiers

PMID39864653
PMCPMC11859754

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.