Observational studyEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2025
Sleep characteristics and intervertebral disc degeneration risk: an observational and Mendelian randomization study.
Observational study in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- The role of sleep and circadian rhythms in intervertebral disc degeneration.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Review
- Association Between Sarcopenia and the Long-Term Risk of Intervertebral Disc Degeneration.Journal of cachexia, sarcopenia and muscle · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
objectivesSleep disorders are considered a risk factor for aging and skeletal degeneration, but their impact on intervertebral disc degeneration (IDD) remains unclear. The aim of this study was to assess associations between sleep characteristics and IDD, and to identify potential causal relationships.
methodsExposure factors included six unhealthy sleep characteristics: insomnia, short sleep duration (< 7 h), long sleep duration (≥ 9 h), evening chronotype, daytime sleepiness, and snoring. The primary outcomes included cervical disc degeneration (CDD) and lumbar disc degeneration (LDD). Firstly, we examined the associations between sleep characteristics and IDD risk in 368,348 participants from the UK Biobank using Cox proportional hazards model. Two-sample Mendelian randomization (MR) analyses were conducted to validate associations found in observational analyses, using genome-wide association data from the UK Biobank and FinnGen consortia.
resultsDuring a median follow-up time of 13.8 years, a total of 1,637 cases of CDD and 7,654 cases of LDD were identified. Observational analyses found that almost all unhealthy sleep characteristics were associated with an elevated risk of IDD, except snoring. Conversely, the risk of IDD decreased linearly with an increasing number of healthy sleep characteristics. MR analyses supported a causal association between genetically determined insomnia and increased risk of LDD (OR 1.25 [1.07-1.47]), and between short sleep duration and increased risk of both IDD phenotypes (OR 5.41 [1.95-15.01] for CDD; OR 3.48 [1.76-6.89] for LDD). However, long sleep duration was causally associated with a reduced risk of LDD (OR 0.13 [0.03-0.53]), which contrasts with the observational findings.
conclusionWe found associations between multiple sleep characteristics and IDD risk and confirmed that insomnia and short sleep duration increased IDD risk. Although more research is needed to confirm the underlying mechanisms, prioritizing interventions to improve sleep quality and ensure adequate sleep could help mitigate IDD.
Indexed as
Identifiers
39865174What Socratic holds
Registered trials
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