ArticleBMC medicine2025
Obstructive sleep apnea and structural and functional brain alterations: a brain-wide investigation from clinical association to genetic causality.
Article in BMC medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Altered Cerebellar Spontaneous Activity and Its Association with Arousal Index in Comorbid Insomnia and Obstructive Sleep Apnea: A Resting-State fMRI Study.Journal of clinical medicine · 2026Article
- Increased MRI-derived parenchymal cerebral spinal fluid mapping in untreated obstructive sleep apnea patients.Neurobiology of disease · 2026Article
- Tract-specific white matter changes and their cognitive correlates in obstructive sleep apnea: a cross-sectional study using 3.0 T diffusion tensor imaging.Sleep & breathing = Schlaf & Atmung · 2026Article
- Utility of gait biomarkers in screening for obstructive sleep apnea among patients with Parkinson's disease: a cross-sectional study.BMC neurology · 2026Article
- Obstructive Sleep Apnea and Hypercoagulability: Combining Observational and Mendelian Randomization Analyses to Explore Causal Relationships.Nature and science of sleep · 2026Article
- Brain Age Acceleration on MRI Due to Poor Sleep: Associations, Mechanisms, and Clinical Implications.Brain sciences · 2025Review
- Sleep apnea and orofacial pain: an integrative clinical perspective.Journal of oral & facial pain and headache · 2025Review
- Distinct EEG spectral and functional connectivity patterns in obstructive sleep apnea patients with excessive daytime sleepiness.Sleep & breathing = Schlaf & Atmung · 2025Article
- Impaired Topological Architecture of Structural Brain Networks in Obstructive Sleep Apnea: A DTI Study.Nature and science of sleep · 2025Article
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10 authors.
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Abstract
backgroundObstructive sleep apnea (OSA) is linked to brain alterations, but the specific regions affected and the causal associations between these changes remain unclear.
methodsWe studied 20 pairs of age-, sex-, BMI-, and education- matched OSA patients and healthy controls using multimodal magnetic resonance imaging (MRI) from August 2019 to February 2020. Additionally, large-scale Mendelian randomization analyses were performed using genome-wide association study (GWAS) data on OSA and 3935 brain imaging-derived phenotypes (IDPs), assessed in up to 33,224 individuals between December 2023 and March 2024, to explore potential genetic causality between OSA and alterations in whole brain structure and function.
resultsIn the cohort study, OSA patients exhibited significantly lower fractional amplitude of low-frequency fluctuation and regional homogeneity in the right posterior cerebellar lobe and bilateral superior and middle frontal gyrus, while showing higher levels in the left occipital lobe and left posterior central gyrus. Decreased fractional anisotropy (FA) but increased apparent diffusion coefficient (ADC) was shown in the bilateral superior longitudinal fasciculus. According to the results of Affiliation file 2: table s6, it is the ADC value of right superior longitudinal fasciculus was shown a positive correlation with the lowest oxygen saturation. In the Mendelian randomization analyses, the area of left inferior temporal sulcus (OR: 0.89; 95% CI: 0.82-0.96), rfMRI connectivity ICA100 edge 893 (OR: 0.88; 95% CI: 0.82-0.96), ICA100 edge 951 (OR: 0.89; 95% CI: 0.82-0.97), and ICA100 edge 1213 (OR: 0.89; 95% CI: 0.82-0.96) were significantly decreased in OSA. Conversely, mean thickness of G-front-inf-Triangul in right hemisphere (OR: 1.14; 95% CI: 1.05-1.23), mean orientation dispersion index in right tapetum (OR: 1.13; 95% CI: 1.04-1.23), and rfMRI connectivity ICA100 edge 258 (OR: 1.13; 95% CI: 1.04-1.22) showed opposite results.
conclusionsNerve fiber damage and imbalances in neuronal activity across multiple brain regions caused by hypoxia, particularly the frontal lobe, underlie the structural and the functional connectivity impairments in OSA.
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