ArticleArthritis & rheumatology (Hoboken, N.J.)2025
Proinflammatory Dietary Pattern and the Risk of Female Gout: Sex-Specific Findings From Three Prospective Cohort Studies.
Article in Arthritis & rheumatology (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Reply.Arthritis & rheumatology (Hoboken, N.J.) · 2025Article
- Empirical dietary index for lower urate concentrations and risk of gout: evidence from cohort studies.The American journal of clinical nutrition · 2025Article
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8 authors.
Funding
Abstract
objectiveWe aimed to determine whether a proinflammatory dietary pattern (mechanism-based diet) is associated with incident female gout in two large cohorts of US women.
methodsWe prospectively observed 79,104 women from the Nurses' Health Study (1984-2016) and 94,382 women from the Nurses' Health Study II (1991-2017); 45,445 men from the Health Professionals Follow-up Study (1986-2016) served as a comparison cohort. Validated food frequency questionnaires were used to calculate Empirical Dietary Inflammatory Pattern (EDIP) (food-based index predictive of circulating inflammatory biomarkers) scores every four years. Cox proportional hazards models were used to evaluate multivariable associations between EDIP and incident, physician-diagnosed gout. We further tested whether these associations were independent of key guideline-based healthy eating patterns that previously showed beneficial associations with gout (ie, Dietary Approaches to Stop Hypertension [DASH], Alternative Healthy Eating Index [AHEI]).
resultsWe documented 5,425 incident female gout cases over 4,372,243 person-years. EDIP was positively associated with female gout risk; hazard ratio (HR) (95% confidence interval [CI]) for the most versus least proinflammatory quintile was 2.02 (1.83-2.22). Additional adjustment for body mass index attenuated this association (HR 1.71 [95% CI 1.55-1.88]). Reversing the EDIP score, women in the most anti-inflammatory EDIP quintile had the largest magnitude of protective association for gout (HR 0.58 [95% CI 0.53-0.65]) compared with HRs for healthiest DASH (HR 0.80 [95% CI 0.73-0.87]) and AHEI quintiles (HR 0.81 [95% CI 0.74-0.89]). The magnitude of association between EDIP and male gout was substantially smaller (HR 1.24 [95% CI 1.13-1.37]; P-heterogeneity <0.0001).
conclusionThese findings support a pivotal role of inflammation as a potential modulator between diet and gout onset, particularly among women.
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