Evidence map›Paper›PMID 39866464›Full record

ArticleHeliyon2025

Clusterin induced by OPC phagocytosis blocks IL-9 secretion to inhibit myelination in a model of Alzheimer's disease.

Rebecca M Beiter, Tula P Raghavan, Olivia Suchocki, Hannah E Ennerfelt, Courtney R Rivet-Noor, Andrea R Merchak, Jennifer L Phillips, Tim Bathe, John R Lukens, Stefan Prokop and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rebecca M BeiterCenter for Brain Immunology and Glia, Department of Neuroscience, Charlottesville, VA 22908, USA.
Tula P RaghavanCenter for Brain Immunology and Glia, Department of Neuroscience, Charlottesville, VA 22908, USA.
Olivia SuchockiCenter for Brain Immunology and Glia, Department of Neuroscience, Charlottesville, VA 22908, USA.
Hannah E EnnerfeltCenter for Brain Immunology and Glia, Department of Neuroscience, Charlottesville, VA 22908, USA.
Courtney R Rivet-NoorCenter for Brain Immunology and Glia, Department of Neuroscience, Charlottesville, VA 22908, USA.
Andrea R MerchakCenter for Brain Immunology and Glia, Department of Neuroscience, Charlottesville, VA 22908, USA.
Jennifer L PhillipsCenter for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.
Tim BatheCenter for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.
John R LukensCenter for Brain Immunology and Glia, Department of Neuroscience, Charlottesville, VA 22908, USA.
Stefan ProkopCenter for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.
Jeffrey L DupreeDepartment of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA 23298, USA.
Alban GaultierCenter for Brain Immunology and Glia, Department of Neuroscience, Charlottesville, VA 22908, USA.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007267 · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · 1985 to 2005
$1.8M
Understanding the impact of Clusterin on the oligodendrocyte lineage in ADRF1AG079520 · UNIVERSITY OF VIRGINIA · 2025 to 2025
$1.1M
Training in the Pharmacological SciencesT32GM148379 · UNIVERSITY OF VIRGINIA · 2025 to 2025
$374k
Brain, Immunology and Glia Training ProgramT32NS115657 · UNIVERSITY OF VIRGINIA · 2025 to 2025
$248k
NIAID NIH HHS F31 AI174782NIA NIH HHS R21 AG083330NIA NIH HHS RF1 AG079520NIGMS NIH HHS T32 GM007267NIGMS NIH HHS T32 GM148379NINDS NIH HHS R21 NS111204NINDS NIH HHS T32 NS115657
6 · The paper itself

Abstract

Background: Variants in the Methods: We employed a combination of immunofluorescence and transmission electron microscopy techniques, primary culture of OPCs, and an animal model of Alzheimer's disease. Results: We found that phagocytosis of debris such as amyloid beta, myelin, and apoptotic cells, increases clusterin expression in oligodendrocyte progenitors. We further discovered that exposure to clusterin inhibits differentiation of oligodendrocyte progenitors. Mechanistically, clusterin blunts production of IL-9 and addition of exogenous IL-9 can rescue clusterin-inhibited myelination. Lastly, we demonstrate that clusterin deletion in mice prevents myelin loss in the 5XFAD model. Discussion: Our data suggest that clusterin could play a key role in Alzheimer's disease myelin pathology.

Indexed as

Alzheimer's diseaseAstrocyteClusterinIL-9MyelinOligodendrocyte progenitor cells

Identifiers

PMID39866464
PMCPMC11761289

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.