Evidence map›Paper›PMID 39866843›Full record

ArticleFrontiers in cell and developmental biology2024

Molecular dynamics of chemotactic signalling orchestrates dental pulp stem cell fibrosis during aging.

Tianmeng Sun, Qing Zhong, Xiaoyi Yu, Huanyu Luo, Feilong Ren, Cangwei Liu, Peng Chen, Fabian Flores-Borja, Hongchen Sun, Zhengwen An

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tianmeng Sun *Department of Oral Biology, School and Hospital of Stomatology, Jilin University, Changchun, China.
Qing Zhong *Department of Oral Biology, School and Hospital of Stomatology, Jilin University, Changchun, China.
Xiaoyi YuDepartment of Oral Biology, School and Hospital of Stomatology, Jilin University, Changchun, China.
Huanyu LuoDepartment of Oral Biology, School and Hospital of Stomatology, Jilin University, Changchun, China.
Feilong RenDepartment of Oral Biology, School and Hospital of Stomatology, Jilin University, Changchun, China.
Cangwei LiuDepartment of Oral Pathology, School and Hospital of Stomatology, Jilin University, Changchun, China.
Peng ChenDepartment of Genetics, College of Basic Medical Sciences, Jilin University, Changchun, China.
Fabian Flores-BorjaCentre for Oral Immunobiology and Regenerative Medicine, Barts and the London School of Medicine and Dentistry, Blizard Institute, Queen Mary University of London, London, United Kingdom.
Hongchen SunDepartment of Oral Pathology, School and Hospital of Stomatology, Jilin University, Changchun, China.
Zhengwen AnDepartment of Oral Biology, School and Hospital of Stomatology, Jilin University, Changchun, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging often triggers dental pulp fibrosis, resulting in clinical repercussions such as increased susceptibility to dental infections, compromised tooth vitality, and reduced responsiveness to dental interventions. Despite its prevalence, the precise molecular mechanisms underlying this condition remains unclear. Leveraging single-cell transcriptome analysis from both our own and publicly available datasets, we identified Ccrl2

Indexed as

chemotactic signalsdental pulp agingfibrosisimmune-fibroblast axissingle cell analysis

Identifiers

PMID39866843
PMCPMC11760607

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.