Evidence map›Paper›PMID 39866882›Full record

ArticleResearch square2025

Micropillar-induced changes in cell nucleus morphology enhance bone regeneration by modulating the secretome.

Xinlong Wang, Yiming Li, Zitong Lin, Indira Pla, Raju Gajjela, Basil Baby Mattamana, Maya Joshi, Yugang Liu, Huifeng Wang, Amy B Zun and 11 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Xinlong WangCenter for Advanced Regenerative Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0001-8978-2851
Yiming LiDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0003-2111-3939
Zitong LinDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Indira PlaProteomics Center of Excellence, Northwestern University, Evanston, IL 60208, USA.
Raju GajjelaProteomics Center of Excellence, Northwestern University, Evanston, IL 60208, USA.
Basil Baby MattamanaProteomics Center of Excellence, Northwestern University, Evanston, IL 60208, USA.
Maya JoshiCenter for Advanced Regenerative Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-6028-475X
Yugang LiuCenter for Advanced Regenerative Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0001-5304-3459
Huifeng WangCenter for Advanced Regenerative Engineering, Northwestern University, Evanston, IL 60208, USA.
Amy B ZunCenter for Advanced Regenerative Engineering, Northwestern University, Evanston, IL 60208, USA.
Hao WangMolecular Oncology Laboratory, Department of Orthopedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA.
Ching-Man WaiCenter for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Vasundhara AgrawalDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-0913-9298
Cody L DuntonDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Chongwen DuanCenter for Advanced Regenerative Engineering, Northwestern University, Evanston, IL 60208, USA.
Bin JiangCenter for Advanced Regenerative Engineering, Northwestern University, Evanston, IL 60208, USA.
Vadim BackmanCenter for Advanced Regenerative Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-1981-1818
Tong-Chuan HeCenter for Advanced Regenerative Engineering, Northwestern University, Evanston, IL 60208, USA.
Russell R ReidCenter for Advanced Regenerative Engineering, Northwestern University, Evanston, IL 60208, USA.
Yuan LuoDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0003-0195-7456
Guillermo A AmeerCenter for Advanced Regenerative Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0001-6023-048X

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
TR&D 7: Cell Specific ProteomicsP41GM108569 · NIGMS · NORTHWESTERN UNIVERSITY · PI KELLEHER, NEIL L · 2015 to 2024
$13.6M
Technology Development UnitU54CA268084 · NCI · NORTHWESTERN UNIVERSITY · PI Daniela E Matei · 2022 to 2026
$10.0M
Reducing Cancer Transcriptional Heterogeneity through Regulation of Chromatin StructureR01CA228272 · NCI · NORTHWESTERN UNIVERSITY · PI BACKMAN, VADIM, ROY, HEMANT K. · 2018 to 2022
$3.2M
Acquisition of a Thermo Fisher Scientific Q Exactive UHMR mass spectrometerS10OD025194 · OD · NORTHWESTERN UNIVERSITY · PI COMPTON, PHILIP DANIEL · 2018 to 2018
$795k
NCI NIH HHS P30 CA060553NCI NIH HHS R01 CA228272NCI NIH HHS U54 CA268084NIGMS NIH HHS P41 GM108569NIH HHS S10 OD025194
6 · The paper itself

Abstract

Nuclear morphology, which modulates chromatin architecture, plays a critical role in regulating gene expression and cell functions. While most research has focused on the direct effects of nuclear morphology on cell fate, its impact on the cell secretome and surrounding cells remains largely unexplored, yet is especially crucial for cell-based therapies. In this study, we fabricated implants with a micropillar topography using methacrylated poly(octamethylene citrate)/hydroxyapatite (mPOC/HA) composites to investigate how micropillar-induced nuclear deformation influences cell paracrine signaling for osteogenesis and cranial bone regeneration.

Identifiers

PMID39866882
PMCPMC11760244

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.