Evidence map›Paper›PMID 39868035›Full record

ArticleiScience2025

Deep learning uncovers histological patterns of YAP1/TEAD activity related to disease aggressiveness in cancer patients.

Benoit Schmauch, Vincent Cabeli, Omar Darwiche Domingues, Jean-Eudes Le Douget, Alexandra Hardy, Reda Belbahri, Charles Maussion, Alberto Romagnoni, Markus Eckstein, Florian Fuchs and 26 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Leveraging AI for cell biology discovery.Biochemical Society transactions · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Benoit SchmauchOwkin France, Paris, France.
Vincent CabeliOwkin France, Paris, France.
Omar Darwiche DominguesOwkin France, Paris, France.
Jean-Eudes Le DougetOwkin France, Paris, France.
Alexandra HardyOwkin France, Paris, France.
Reda BelbahriOwkin France, Paris, France.
Charles MaussionOwkin France, Paris, France.
Alberto RomagnoniOwkin France, Paris, France.
Markus EcksteinBavarian Cancer Research Center (Bayerisches Zentrum für Krebsforschung, BZKF), Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Institute of Pathology, University Hospital Erlangen, Erlangen, Germany.
Florian FuchsBavarian Cancer Research Center (Bayerisches Zentrum für Krebsforschung, BZKF), Erlangen, Germany.
Aurélie SwalduzClaude Bernard University Lyon I & Léon Bérard Cancer Center, Lyon, France.
Sylvie LantuejoulGrenoble Alpes University and Léon Bérard Cancer Center, Lyon, France.
Hugo CrochetLéon Bérard Cancer Center, Lyon, France.
François GhiringhelliCentre de Recherche INSERM LNC-UMR1231, Dijon, France.
Valentin DerangereCentre de Recherche INSERM LNC-UMR1231, Dijon, France.
Caroline TruntzerCentre de Recherche INSERM LNC-UMR1231, Dijon, France.
Harvey PassDepartment of Cardiothoracic Surgery, New York University Langone Medical Center, New York, NY, USA.
Andre L MoreiraDepartment of Pathology, NYU Langone New York University Langone Medical Center, New York, NY, USA.
Luis ChiribogaDepartment of Pathology, NYU Langone New York University Langone Medical Center, New York, NY, USA.
Yuanning ZhengDepartment of Pathology, Stanford University, Stanford, CA, USA.
Michael OzawaDepartment of Pathology, Stanford University, Stanford, CA, USA.
Brooke E HowittDepartment of Medicine & Biomedical Data Science, Stanford University, Stanford, CA, USA.
Olivier GevaertDepartment of Medicine & Biomedical Data Science, Stanford University, Stanford, CA, USA.
Nicolas GirardInstitut Curie, Paris, France.
Elton RexhepajSanofi, Paris, France.
Iris ValtingojerSanofi, Paris, France.
Laurent DebusscheSanofi, Paris, France.
Emanuele de RinaldisSanofi, Cambridge, MA, USA.
Frank NestleSanofi, Cambridge, MA, USA.
Emmanuel SpanakisSanofi, Paris, France.
Valeria R FantinSanofi, Cambridge, MA, USA.
Eric Y DurandOwkin France, Paris, France.
Marion ClasseSanofi, Paris, France.
Katharina Von LogaOwkin France, Paris, France.
Elodie PronierOwkin France, Paris, France.
Matteo CesaroniSanofi, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the last decade, Hippo signaling has emerged as a major tumor-suppressing pathway. Its dysregulation is associated with abnormal expression of

Indexed as

Applied sciencesHealth sciencesMachine learning

Identifiers

PMID39868035
PMCPMC11758823

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.