Evidence map›Paper›PMID 39871555›Full record

ArticleCombinatorial chemistry & high throughput screening2026

PGD2/PTGDR2 Signaling Affects the Stemness of Gastric Cancer Stem Cells by Regulating Autophagy.

Feifan Wang, Hengjin Tian, Peiyao Gao, Zhanshan Cha, Qiang Zhang

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Article in Combinatorial chemistry & high throughput screening, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Feifan WangDepartment of Blood Transfusion, The First Affiliated Hospital of Naval Medical University, Shanghai, China.
Hengjin TianDepartment of Clinical Laboratory, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Peiyao GaoDepartment of Blood Transfusion, Fuyang Woman's and Children's Hospital, Fuyang, China.
Zhanshan ChaDepartment of Blood Transfusion, The First Affiliated Hospital of Naval Medical University, Shanghai, China.
Qiang ZhangDepartment of Clinical Laboratory, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.

Funding

Anhui Provincial Natural Science Foundation 1908085MH258Cultivation Project of Discipline Leaders in Anhui Province DTR2024029Key scientific research project of the Health Commission of Anhui Province AHWJ2023A10057
6 · The paper itself

Abstract

backgroundProstaglandin D2 (PGD2) can inhibit the development of gastric cancer (GC); however, its role in the autophagic death of GC stem cells (GCSCs) remains elusive. Therefore, this study aims to evaluate the mechanisms by which PGD2 regulates the stemness in GCSCs.

methodsIn this study, HGC27-derived GCSCs were employed to knock down PGD2 receptor 2 (PTGDR2). Subsequently, cell stemness and autophagic activity in these GCSCs were assessed

resultsThe results revealed that PGD2 suppressed the stemness of GCSCs and induced GCSCs autophagy, whereas the downregulation of PTGDR2 had the opposite effect. Furthermore, PGD2 was also found to inhibit the expression of stemness-associated proteins CD44 and OCT4, which were blocked by 3-MA and enhanced by RAPA. Moreover, the shPTGDR2 + PGD2 group indicated higher stemness than the PGD2 group, with 3-MA enhancing this effect and RAPA reducing this change.

conclusionIn summary, this study indicated that PGD2/PTGDR2 signaling affects stemness and autophagy in GCSCs. The results suggest that PGD2/PTGDR2 signaling may affect the stemness of GCSCs by regulating autophagy.

Indexed as

AutophagyNeoplastic Stem CellsProstaglandin D2Receptors, ImmunologicReceptors, ProstaglandinStomach NeoplasmsCell Line, TumorHumansSignal TransductionProstaglandin D2prostaglandin D2 receptorReceptors, ImmunologicReceptors, ProstaglandinautophagyGastric cancerprostaglandin D2PTGDR2stem cellsstemness.

Identifiers

PMID39871555

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.