Evidence map›Paper›PMID 39871566›Full record

ArticleAnti-cancer agents in medicinal chemistry2025

Cytotoxic Effects of

Roshudufhadzwa Magadani, Derek Tantoh Ndinteh, Saartjie Roux, Louisiane Patrick Nangah, Item Justin Atangwho, Daniel Ejim Uti, Esther Ugo Alum, Simeon Ikechukwu Egba

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Article in Anti-cancer agents in medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Roshudufhadzwa MagadaniDepartment of Chemical Science, Faculty of Science, University of Johannesburg, Doornfontein, 2028, South Africa.
Derek Tantoh NdintehDepartment of Chemical Science, Faculty of Science, University of Johannesburg, Doornfontein, 2028, South Africa.
Saartjie RouxDepartment of Physiology, Faculty of Science, Nelson Mandela University, Summerstrand, 6019, South Africa.
Louisiane Patrick NangahDepartment of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, P.M.B. 1115, Calabar, Nigeria.
Item Justin AtangwhoDepartment of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, P.M.B. 1115, Calabar, Nigeria.
Daniel Ejim UtiDepartment of Research Publications, Kampala International University, Main Campus, P. O. Box 20000, Kampala, Uganda.
Esther Ugo AlumDepartment of Research Publications, Kampala International University, Main Campus, P. O. Box 20000, Kampala, Uganda.
Simeon Ikechukwu EgbaDepartment of Research Publications, Kampala International University, Main Campus, P. O. Box 20000, Kampala, Uganda.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prevalent disease known as breast cancer has a significant impact on both men's and women's health and quality of life.

aimThe aim of this study was to explore the potential roles of

methodsGold nanoparticles were synthesized utilizing triterpenoid (ZJ-AuNPs) and leaf extract from

resultsAnalysis of ZJ-AuNPs and LC-AuNPs revealed DLS zeta potentials of -31.8 and -35.8 mV, respectively, and a corresponding UV-vis absorption maxima at 540 and 550 nm. Also, the ZJ-AuNPs and LC-AuNPs had respective zeta-sizes that ranged from 25.84 to 35.98 nm and polydispersive index values between 0.2360 and 0.773. Furthermore, the presence of the chemical groups -OH and -NH was shown to be necessary for the green method of capping and reducing the gold nanoparticles. Nevertheless, a significant decrease in cell viability percentages was noted in the MTT experiment, accompanied by an increase in the quantity or concentration of the nanoparticles for both ZJ-AuNPs and LC-AuNPs.

conclusionGiven the data obtained in this study, the biosynthesized ZJ-AuNPs and LC-AuNPs were shown to possess potent cytotoxic effects on breast cancer cells. Hence, they may be valuable tools in the development of new cancer chemotherapy drugs.

Indexed as

Antineoplastic AgentsAntineoplastic Agents, PhytogenicBreast NeoplasmsGoldMetal NanoparticlesPlant ExtractsTriterpenesCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMCF-7 CellsMolecular StructureParticle SizeStructure-Activity RelationshipAntineoplastic AgentsAntineoplastic Agents, PhytogenicGoldPlant ExtractsTriterpenesbiosynthesized gold nanoparticlescancer therapy.Lecaniodiscus cupanioides extractMCF-7 breast cancer cell linesMTT assaytriterpenoids

Identifiers

PMID39871566

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.