Evidence map›Paper›PMID 39871574›Full record

ArticleCurrent pharmaceutical biotechnology2026

HYQTD Drug-containing Serum Alleviates H

Jin Wu, Lijuan Chen, Ying Du, Xue Leng, Dongchao Yuan, Mingqian Yang, Yeyu Zhao, Bin Lv, Lianqun Jia

Abstract read
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In one paragraph

Article in Current pharmaceutical biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jin WuKey Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications, Liaoning University of Traditional Chinese Medicine, Shenyang, China.
Lijuan ChenKey Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications, Liaoning University of Traditional Chinese Medicine, Shenyang, China.
Ying DuKey Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications, Liaoning University of Traditional Chinese Medicine, Shenyang, China.
Xue LengCollege of Integrated Chinese and Western Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang, China.
Dongchao YuanCollege of Traditional Chinese Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang, China.
Mingqian YangCollege of Traditional Chinese Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang, China.
Yeyu ZhaoThe Department of Rheumatology, Liaoning University of Traditional Chinese Medicine Affiliated Hospital Shenyang, China.
Bin LvHengyang Medical School, University of South China, Hengyang, China.
Lianqun JiaKey Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications, Liaoning University of Traditional Chinese Medicine, Shenyang, China.

Funding

Joint Project Foundation of Science and Technology Department of Liaoning Province 2023-BSBA-222Open Fund Project of the Key Laboratory of the Ministry of Education for Traditional Chinese Medicine Visera-State Theory and Application zyzx1906
6 · The paper itself

Abstract

backgroundAtherosclerosis (AS) is caused by the endothelium injury associated with oxidative stress. Previous studies have shown that the Phlegm-Eliminating and Stasis- Transforming Decoction (Huayu Qutan Decoction, HYQTD) has mitochondrial protective function. The objective of this research was to explore how HYQTD drug-containing serum (HYQTD-DS) could potentially protect mitochondrial energy production in endothelial cells (ECs) from injury caused by hydrogen peroxide (H

methodsAfter preparation of containing serum, the cells were divided into various categories, such as control group, H

resultsWe found oxidative stress, mitochondrial damage, and mitochondrial energy disorder in H

conclusionWe demonstrated that HYQTD-DS attenuated oxidative stress, improved mitochondrial function, and up-regulated mitochondrial ATP synthesis by activating SIRT1/PGC- 1α/Nrf2 pathway-induced mitochondrial biogenesis and its downstream NADH dehydrogenase (ubiquinone) flavoprotein 2 (NDV2).

Indexed as

Adenosine TriphosphateDrugs, Chinese HerbalEndothelial CellsMitochondriaOxidative StressAnimalsAtherosclerosisCells, CulturedHydrogen PeroxideNF-E2-Related Factor 2Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaReactive Oxygen SpeciesSirtuin 1Adenosine TriphosphateDrugs, Chinese HerbalHydrogen PeroxideNF-E2-Related Factor 2Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, ratReactive Oxygen SpeciesSirt1 protein, ratSirtuin 1mitochondrial ATP synthesismitochondrial biogenesismitochondrial dysfunction.oxidative stressTraditional Chinese medicinevascular endothelial injury

Identifiers

PMID39871574

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.