Evidence map›Paper›PMID 39873715›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Evidence for the anxiolytic- and antidepressant-like effects of three semi-synthetic derivatives of xylopic acid in mice.

Charles Kwaku Benneh, Wonder Kofi Mensah Abotsi, Priscilla Kolibea Mante, Robert Peter Biney, John Peter Fetse, Mustapha Kobina Abeka, Donatus Wewura Adongo, Eric Woode

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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Charles Kwaku BennehDepartment of Clinical Pharmacy and Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine, UK.
Wonder Kofi Mensah AbotsiDepartment of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. wkmabotsi.pharm@knust.edu.gh.ORCID 0000-0002-0021-4231
Priscilla Kolibea ManteDepartment of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Robert Peter BineyDepartment of Pharmacotherapeutics and Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, University of Cape Coast, Cape Coast, Ghana.
John Peter FetseDepartment of Pharmaceutical Sciences, College of Pharmacy, Larkin University, Miami, FL, USA.
Mustapha Kobina AbekaDepartment of Pharmaceutical Chemistry, School of Pharmacy and Pharmaceutical Sciences, University of Cape Coast, Cape Coast, Ghana.
Donatus Wewura AdongoDepartment of Pharmacology and Toxicology, School of Pharmacy, University of Health and Allied Sciences, Ho, Ghana.
Eric WoodeDepartment of Pharmacology and Toxicology, School of Pharmacy, University of Health and Allied Sciences, Ho, Ghana.

Funding

University of Health and Allied Sciences, Ghana UHAS-RF/CI/SG-008
6 · The paper itself

Abstract

purposeMajor depressive disorder is one of the most common and burdensome psychiatric disorders worldwide. This study evaluated the anxiolytic- and antidepressant-like activity of three semi-synthetic derivatives of xylopic acid (XA) to identify the most promising derivative based on mechanism(s) of action, in vivo pharmacokinetics and in vitro cytotoxicity.

methodsThe anxiolytic potential and the involvement of GABAergic mechanisms were assessed in the elevated plus-maze and open field tests in mice. The antidepressant-like effects were also investigated in the tail suspension test (TST) and forced swim test (FST). Possible mechanism(s) of antidepressant-effect was assessed by selective depletion of monoamines, using either reserpine, alpha-methyl-para-tyrosine or para-chlorophenylalanine (pCPA) prior to repeating the TST and FST. A single oral (100 mg kg

resultsXA and all the derivatives (10-100 mg kg

conclusionAll the semi-synthetic derivatives of XA exert varying degrees of anxiolytic- and antidepressant-like effects in mice. The anxiolytic- and antidepressant-like effects of dXA and XA are mediated, at least partly, through GABAergic and serotoninergic systems, respectively. In comparison with XA, dXA has a much lower clearance, longer half-life, shorter time to reach peak plasma concentration and was less toxic to HepG2 cells.

Indexed as

Anti-Anxiety AgentsAntidepressive AgentsAnimalsBehavior, AnimalCaco-2 CellsDepressionHep G2 CellsHindlimb SuspensionHumansMaleMaze LearningMiceAnti-Anxiety AgentsAntidepressive AgentsAntidepressantAnxiolyticDeacetylated xylopic acidXylopic acid

Identifiers

PMID39873715

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.