Evidence map›Paper›PMID 39874294›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Suppressing APOE4-induced neural pathologies by targeting the VHL-HIF axis.

Wei I Jiang, Yiming Cao, Yue Xue, Yichun Ji, Benjamin Y Winer, Rashmi Chandra, Xingyuan Fischer Zhang, Mengqi Zhang, Neel S Singhal, Jonathan T Pierce and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wei I JiangCardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158.ORCID 0000-0002-6394-635X
Yiming CaoJiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
Yue XueJiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
Yichun JiJiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.ORCID 0009-0003-2323-7019
Benjamin Y WinerCardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158.
Rashmi ChandraCardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158.
Xingyuan Fischer ZhangCardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158.
Mengqi ZhangDepartment of Neurology, University of California San Francisco, San Francisco, CA 94158.
Neel S SinghalDepartment of Neurology, University of California San Francisco, San Francisco, CA 94158.
Jonathan T PierceDepartment of Neuroscience, The Center for Learning and Memory, Waggoner Center for Alcohol and Addiction Research, Institute of Neuroscience, University of Texas at Austin, Austin, TX 78712.
Song ChenJiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
Dengke K MaCardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158.ORCID 0000-0002-5619-7485

Funding

The Patient-Reported Outcomes, Community-Engagement and Language (PRO-CEL) CoreP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · 1985 to 2025
$88.4M
Center for C elegans AnatomyR24OD010943 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2023 to 2025
$2.1M
Genetic pathway and cellular mechanism underlying organismic responses to hypoxia and hypothermiaR35GM139618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2022 to 2025
$1.5M
WormBase: a core data resource for C. elegans and other nematodesU24HG002223 · CALIFORNIA INSTITUTE OF TECHNOLOGY · 2025 to 2025
$1.4M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · UNIVERSITY OF MINNESOTA · 2025 to 2025
$455k
HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM139618NCI NIH HHS P30 CA008748NHGRI NIH HHS U24 HG002223NIA NIH HHS RF1 AG057355NIGMS NIH HHS R35 GM139618NIH HHS P40 OD010440NIH HHS R21 OD032463NIH HHS R24 OD010943
6 · The paper itself

Abstract

The ε4 variant of human apolipoprotein E (

Indexed as

Alzheimer DiseaseApolipoprotein E4Caenorhabditis elegans ProteinsHypoxia-Inducible Factor 1Von Hippel-Lindau Tumor Suppressor ProteinAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansHumansMiceMice, TransgenicOxidative StressTranscription FactorsApolipoprotein E4Caenorhabditis elegans ProteinsHIF-1 protein, C elegansHypoxia-Inducible Factor 1Transcription FactorsVon Hippel-Lindau Tumor Suppressor ProteinAPOE4mitochondrial dysfunctionneurodegenerationoxidative stressVHL–HIF axis

Identifiers

PMID39874294
PMCPMC11804744

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.