Evidence map›Paper›PMID 39874431›Full record

ReviewJournal of neurochemistry2025

Prion Protein Endoproteolysis: Cleavage Sites, Mechanisms and Connections to Prion Disease.

Andrew R Castle, David Westaway

Abstract readReview
In one paragraph

Review in Journal of neurochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Andrew R CastleNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID 0000-0003-2590-9555
David WestawayCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Canada.ORCID 0000-0003-1928-4616

Funding

Alberta Prion Research Institute APRIIEP201600033Campus Alberta NeuroscienceCIHR PS165980Co-funders: Alzheimer Society of Alberta and Northwest Territories; and the University Hospital Foundation of the University of Alberta "Hope for Tomorrow" program
6 · The paper itself

Abstract

Highly abundant in neurons, the cellular prion protein (PrP

Indexed as

Prion DiseasesPrion ProteinsProteolysisPrPC ProteinsAnimalsHumansPrion ProteinsPrPC Proteins

Identifiers

PMID39874431
PMCPMC11774512

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.