Evidence map›Paper›PMID 39875035›Full record

ArticleInternational journal of pharmaceutics2025

Ultrasound-triggered release of vancomycin from a novel spinal device: Antibiotic release and efficacy in vivo.

Lauren J Delaney, Priscilla Machado, Ji-Bin Liu, Rachel Evans, Asia Winslow, Neil Zhao, Christopher K Kepler, Rajkishen Narayanan, Teeto Ezeonu, Viren Soni and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lauren J DelaneyDepartment of Radiology, Thomas Jefferson University, 132 S. 10(th) Street, Main 10(th) Floor, Philadelphia, PA 19107, USA. Electronic address: lauren.delaney@jefferson.edu.
Priscilla MachadoDepartment of Radiology, Thomas Jefferson University, 132 S. 10(th) Street, Main 10(th) Floor, Philadelphia, PA 19107, USA.
Ji-Bin LiuDepartment of Radiology, Thomas Jefferson University, 132 S. 10(th) Street, Main 10(th) Floor, Philadelphia, PA 19107, USA.
Rachel EvansDepartment of Orthopaedic Surgery, Thomas Jefferson University, 1015 Walnut Street, Suite 501, Philadelphia, PA 19107, USA.
Asia WinslowDepartment of Orthopaedic Surgery, Thomas Jefferson University, 1015 Walnut Street, Suite 501, Philadelphia, PA 19107, USA.
Neil ZhaoDepartment of Orthopaedic Surgery, Thomas Jefferson University, 1015 Walnut Street, Suite 501, Philadelphia, PA 19107, USA.
Christopher K KeplerDepartment of Orthopaedic Surgery, Thomas Jefferson University, 1015 Walnut Street, Suite 501, Philadelphia, PA 19107, USA; Rothman Institute, 925 Chestnut Street, Philadelphia, PA 19107, USA.
Rajkishen NarayananDepartment of Orthopaedic Surgery, Thomas Jefferson University, 1015 Walnut Street, Suite 501, Philadelphia, PA 19107, USA; Rothman Institute, 925 Chestnut Street, Philadelphia, PA 19107, USA.
Teeto EzeonuDepartment of Orthopaedic Surgery, Thomas Jefferson University, 1015 Walnut Street, Suite 501, Philadelphia, PA 19107, USA; Rothman Institute, 925 Chestnut Street, Philadelphia, PA 19107, USA.
Viren SoniCollege of Pharmacy, Thomas Jefferson University, 1025 Walnut Street, Suite 301, Philadelphia, PA 19107, USA.
Gagan KaushalCollege of Pharmacy, Thomas Jefferson University, 1025 Walnut Street, Suite 301, Philadelphia, PA 19107, USA.
Rachel HilliardDepartment of Clinical Studies, New Bolton Center, University of Pennsylvania School of Veterinary Medicine, 382 W Street Road, Kennett Square, PA 19348, USA.
Thomas P SchaerDepartment of Clinical Studies, New Bolton Center, University of Pennsylvania School of Veterinary Medicine, 382 W Street Road, Kennett Square, PA 19348, USA.
Noreen J HickokDepartment of Orthopaedic Surgery, Thomas Jefferson University, 1015 Walnut Street, Suite 501, Philadelphia, PA 19107, USA.
Flemming ForsbergDepartment of Radiology, Thomas Jefferson University, 132 S. 10(th) Street, Main 10(th) Floor, Philadelphia, PA 19107, USA.

Funding

CLINICAL PHARMACOLOGY TRAINING PROGRAMT32GM008562 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI WALTER K KRAFT, Scott A. Waldman · 1995 to 2026
$10.2M
Preventing Spinal Infection: Ultrasound Triggered ProphylaxisR01AR069119 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI Flemming Forsberg, Noreen J Hickok · 2016 to 2026
$3.2M
Ultrasound-Triggered Prophylaxis as a Novel Paradigm for Preventing Spinal InfectionR00AR078354 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI DELANEY, LAUREN JO · 2022 to 2024
$740k
NIAMS NIH HHS R00 AR078354NIAMS NIH HHS R01 AR069119NIGMS NIH HHS T32 GM008562
6 · The paper itself

Abstract

Post-surgical spinal infection occurs in up to 20 % of patients, despite aggressive peri-operative antibiotic treatments. To improve prophylaxis, we have designed and evaluated an ultrasound-activated prophylactic antibiotic release system to combat post-surgical bacterial survival. Polylactic acid (PLA) clips (1 cm

Indexed as

Anti-Bacterial AgentsDrug Delivery SystemsSurgical Wound InfectionVancomycinAnimalsDrug LiberationFemalePolyestersPrinting, Three-DimensionalSheepStaphylococcal InfectionsStaphylococcus aureusSwineUltrasonic WavesAnti-Bacterial AgentsPolyesterspoly(lactide)VancomycinInfectionProphylaxisSpineUltrasound triggered release

Identifiers

PMID39875035
PMCPMC13285313

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.