Evidence map›Paper›PMID 39875685›Full record

Trial reportNature medicine2025

An online multidomain lifestyle intervention to prevent cognitive decline in at-risk older adults: a randomized controlled trial.

Henry Brodaty, Tiffany Chau, Megan Heffernan, Jeewani A Ginige, Gavin Andrews, Michael Millard, Perminder S Sachdev, Kaarin J Anstey, Nicola T Lautenschlager, John J McNeil and 18 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Nature medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07376135 (Digitally Supported Lifestyle Programme to Promote Brain Health Among Older Adults - the LETHE-AT Randomised-controlled, Multicentre Pilot Trial), which is not on this map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07376135 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Digitally Supported Lifestyle Programme to Promote Brain Health Among Older Adults - the LETHE-AT Randomised-controlled, Multicentre Pilot Trial

TypeinterventionalSponsorMedical University of ViennaRan2026 to 2027Enrolled300ConditionsMild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)ArmsA tailored hybrid multidomain lifestyle intervention group, Self-guided multimodal lifestyle advice group
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Observational
  16. Article
  17. Vascular cognitive impairment and dementia: Prevention, treatments, mechanisms and management options for the future.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Henry BrodatyCentre for Healthy Brain Ageing (CHeBA), School of Clinical Medicine, UNSW Sydney, Sydney, New South Wales, Australia. h.brodaty@unsw.edu.au.ORCID http://orcid.org/0000-0001-9487-6617
Tiffany ChauCentre for Healthy Brain Ageing (CHeBA), School of Clinical Medicine, UNSW Sydney, Sydney, New South Wales, Australia.
Megan HeffernanCentre for Healthy Brain Ageing (CHeBA), School of Clinical Medicine, UNSW Sydney, Sydney, New South Wales, Australia.
Jeewani A GinigeSchool of Computer, Data and Mathematical Sciences, Western Sydney University, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-6695-6983
Gavin AndrewsClinical Research Unit for Anxiety and Depression, School of Psychiatry, UNSW Sydney, Sydney, New South Wales, Australia.
Michael MillardClinical Research Unit for Anxiety and Depression, School of Psychiatry, UNSW Sydney, Sydney, New South Wales, Australia.
Perminder S SachdevCentre for Healthy Brain Ageing (CHeBA), School of Clinical Medicine, UNSW Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-9595-3220
Kaarin J AnsteySchool of Psychology, UNSW Sydney, Sydney, New South Wales, Australia.
Nicola T LautenschlagerDepartment of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0003-4850-7794
John J McNeilSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-1049-5129
Louisa JormCentre for Big Data Research in Health, UNSW Sydney, Sydney, New South Wales, Australia.
Nicole A KochanCentre for Healthy Brain Ageing (CHeBA), School of Clinical Medicine, UNSW Sydney, Sydney, New South Wales, Australia.
Anthony MaederCollege of Nursing and Health Sciences, Flinders University, Adelaide, South Australia, Australia.ORCID http://orcid.org/0000-0002-7398-2581
Heidi WelberryCentre for Big Data Research in Health, UNSW Sydney, Sydney, New South Wales, Australia.
Juan Carlo San JoseResearch Technology Services (ResTech), UNSW Sydney, Sydney, New South Wales, Australia.
Nancy E BriggsStats Central, Mark Wainwright Analytical Centre, UNSW Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-1134-0807
Gordana PopovicStats Central, Mark Wainwright Analytical Centre, UNSW Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-1376-1058
Yorgi MavrosSchool of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-2588-0425
Carolina Almendrales RangelSchool of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-8664-563X
Yian NobleSchool of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Sue Radd-VagenasSchool of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0001-8285-5819
Victoria M FloodSchool of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0001-5310-7221
Fiona O'LearySusan Wakil School of Nursing and Midwifery, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Amit LampitDepartment of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia.
Courtney C WaltonMelbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Victoria, Australia.
Polly BarrSchool of Psychological Science, University of Bristol, Bristol, UK.
Maria Fiatarone Singh *School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Michael Valenzuela *Centre for Healthy Brain Ageing (CHeBA), School of Clinical Medicine, UNSW Sydney, Sydney, New South Wales, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Effective, scalable dementia prevention interventions are needed to address modifiable risk factors given global burden of dementia and challenges in developing disease-modifying treatments. A single-blind randomized controlled trial assessed an online multidomain lifestyle intervention to prevent cognitive decline over 3 years. Participants were dementia-free community-dwelling Australians aged 55-77 years with modifiable dementia risk factors. Eligible participants (n = 6,104, 64% female) were randomized 1:1 to a personalized schedule of online coaching in two to four modules (targeting physical activity, nutrition, cognitive activity and depression or anxiety) or a control group that received module-eligible information only. At 3 years, the mean change in a global cognitive composite, the primary outcome, was met. The mean changes in z scores were 0.28 (95% confidence interval (CI): 0.25-0.32) for intervention, 0.10 (95% CI: 0.07-0.13) for control and 0.18 (95% CI: 0.13-0.23, P < 0.001) for the between-group difference. Trial-related adverse events occurred in 19 (0.60%) intervention and 1 (0.03%) control participant. Randomization of this internet-delivered lifestyle intervention tailored to individual dementia risk factors resulted in significantly better cognition in older adults over 3 years. This intervention is scalable with the potential for population-level rollout that may delay cognitive decline in the general community. Australian New Zealand ClinicalTrials.gov registration: ACTRN12618000851268.

Indexed as

Cognitive DysfunctionDementiaLife StyleAgedAustraliaExerciseFemaleHumansInternetMaleMiddle AgedRisk FactorsSingle-Blind Method

Identifiers

PMID39875685

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.