Evidence map›Paper›PMID 39875693›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2025

Screening of Oxidative Stress-related Biomarkers and Antioxidant Drugs for Polycystic Ovary Syndrome Based on Bioinformatics and Molecular Docking.

Lanhui Chen, Tian Li, Jialiang Xu, Siqi Liao, Haocheng Xu, Kun Li, Deyana Ivanova, Yuewen Si, Xin Zhang, Jianning Zhang and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Lanhui Chen *Department of Physiology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China.
Tian Li *Department of Reproductive Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jialiang XuDepartment of Physiology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China.
Siqi LiaoDepartment of Physiology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China.
Haocheng XuDepartment of Physiology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China.
Kun LiDepartment of Physiology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China.
Deyana IvanovaDepartment of Medicine, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Yuewen SiDepartment of Physiology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China.
Xin ZhangDepartment of Physiology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China.
Jianning ZhangDepartment of Physiology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China.
Fangfang LiJoint International Research Laboratory of Reproduction and Development of the Ministry of Education of China, School of Public Health, Chongqing Medical University, Chongqing, 400016, China.
Xuemei ChenJoint International Research Laboratory of Reproduction and Development of the Ministry of Education of China, School of Public Health, Chongqing Medical University, Chongqing, 400016, China.
Yingxiong WangJoint International Research Laboratory of Reproduction and Development of the Ministry of Education of China, School of Public Health, Chongqing Medical University, Chongqing, 400016, China.
Biao XieDepartment of Biostatistics, School of Public Health, Chongqing Medical University, Chongqing, 400016, China.
Dan ShiDepartment of Nutrition and Food Hygiene, School of Public Health, Chongqing Medical University, Chongqing, China. danshi@cqmu.edu.cn.
Meijiao WangDepartment of Physiology, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China. meijiaowang@cqmu.edu.cn.ORCID 0000-0003-2913-745X

Funding

Chongqing Maternal and Child Disease Prevention and Control and Public Health Research Center Open Project CQFYJB01001National Natural Science Foundation of China Nos. 82171624National Natural Science Foundation of China Nos. 82204159Natural Science Foundation of Chongqing Municipality No. cstc2020jcyj-msxmX0294Science and Technology Project of Chongqing Yuzhong District No. 20200103Science and Technology Research Program of Chongqing Municipal Education Commission KJQN202300423
6 · The paper itself

Abstract

Polycystic ovary syndrome (PCOS) is a prevalent endocrine and metabolic disorder affecting women of reproductive age. Oxidative stress (OS) is suggested to play a significant role in the development of PCOS. Using antioxidants to reduce OS and maintain a healthy balance in the body could be a novel treatment approach for PCOS. This study analyzed transcriptome data from the Gene Expression Omnibus database, focusing on genes associated with OS. By implementing two machine learning algorithms, three OS-related biomarkers-HMOX1, MMP9, and KLF2-were successfully identified. To evaluate the diagnostic potential of these biomarkers, a Logistic regression model was employed. Additionally, granulosa cells were collected from healthy individuals and infertile women with PCOS, and the reliability of HMOX1, MMP9, and KLF2 was verified by quantitative real-time PCR experiments. Furthermore, small molecule drugs targeting proteins encoded by genes HMOX1 and MMP9 were predicted through the Drug Signature Database. Molecular docking of drugs to proteins identified two antioxidants, butein and demethoxycurcumin, as potential candidates for PCOS therapy.

Indexed as

AntioxidantsComputational BiologyMolecular Docking SimulationOxidative StressPolycystic Ovary SyndromeAdultBiomarkersFemaleGranulosa CellsHeme Oxygenase-1HumansKruppel-Like Transcription FactorsMatrix Metalloproteinase 9AntioxidantsBiomarkersHeme Oxygenase-1HMOX1 protein, humanKruppel-Like Transcription FactorsMatrix Metalloproteinase 9MMP9 protein, humanAntioxidant drugsBioinformaticsMolecular dockingOxidative stressPolycystic ovary syndrome

Identifiers

PMID39875693

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.