Evidence map›Paper›PMID 39875816›Full record

Observational studyBMC cancer2025

Rationale and design of APOLLO: a personalized rehAbilitation PrOgram in aLLOgeneic bone marrow transplantation.

Edith Pituskin, Stephen Foulkes, Rachel J Skow, Thomas McMurtry, Calvin Kruger, Janet E Bates, Daena Lamoureux, Joseph Brandwein, Elena Lieuw, Cynthia Wu and 15 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05579678 (APOLLO), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05579678 recruitingnot on this map

APOLLO: Personalized rehAbilitation PrOgram in aLLOgeneic Bone Marrow Transplantation

TypeobservationalSponsorUniversity of AlbertaRan2022 to 2026Enrolled45ConditionsAllogeneic DiseaseArmsSupportive nursing, nutritional and physical activity with a handheld 'app'
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Edith PituskinFaculty of Nursing, University of Alberta, Edmonton, AB, Canada. pituskin@ualberta.ca.
Stephen FoulkesFaculty of Nursing, University of Alberta, Edmonton, AB, Canada.
Rachel J SkowFaculty of Nursing, University of Alberta, Edmonton, AB, Canada.
Thomas McMurtryFaculty of Nursing, University of Alberta, Edmonton, AB, Canada.
Calvin KrugerFaculty of Nursing, University of Alberta, Edmonton, AB, Canada.
Janet E BatesFaculty of Nursing, University of Alberta, Edmonton, AB, Canada.
Daena LamoureuxFaculty of Nursing, University of Alberta, Edmonton, AB, Canada.
Joseph BrandweinFaculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.
Elena LieuwFaculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.
Cynthia WuFaculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.
Nancy ZhuFaculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.
Peng WangFaculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.
Daniel SawlerFaculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.
Minakshi TapariaFaculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.
Marlene HamiltonFaculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.
Tiffany Comfort-RiddleAlberta Health Services, Edmonton, AB, Canada.
Tara MeyerAlberta Health Services, Edmonton, AB, Canada.
Gabor T GyenesAlberta Health Services, Edmonton, AB, Canada.
Ian PatersonUniversity of Ottawa Heart Institute, Ottawa, ON, Canada.
Carla M PradoDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada.
Mark J HaykowskyFaculty of Nursing, University of Alberta, Edmonton, AB, Canada.
Justin G GreinerDepartment of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada.
Margaret L McNeelyDepartment of Physical Therapy, University of Alberta, Edmonton, AB, Canada.
Puneeta TandonDepartment of Medicine, Division of Gastroenterology (Liver Unit), University of Alberta, Edmonton, AB, Canada.
Richard B ThompsonDepartment of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada.

Funding

Canadian Cancer Society 933631Leukemia and Lymphoma Society of Canada 933631
6 · The paper itself

Abstract

backgroundHematopoietic stem cell transplantation (HSCT) is a common therapy for many hematologic malignancies. While advances in transplant practice have improved cancer-specific outcomes, multiple and debilitating long term physical and psychologic effects remain. Patients undergoing allogeneic bone marrow transplantation (allo-BMT) are often critically ill at initial diagnosis and with necessary sequential treatments become increasingly frail and deconditioned. Despite modern treatment regimens and support, cardiovascular disease remains a leading cause of non-relapse mortality among allo-BMT survivors. Well-established multi-disciplinary care models such as cardiac rehabilitation offer holistic care including exercise training, nursing support, physical/occupational therapy, psychosocial support and nutritional education. HSCT patients may be excluded from conventional outpatient physical rehabilitation programs due to prolonged pancytopenia and frequent hospital admissions. In Canada, dedicated cancer-specific rehabilitation programs are available only at major tertiary academic centers.

methodsThe primary aim of this study will evaluate the feasibility and acceptability of a multimodal care navigation (nursing, exercise, nutrition) intervention with content delivery facilitated by a supportive care web-based 'app' extending from diagnosis to 1 year in the allogeneic bone marrow transplant population. Adult patients scheduled for allo-BMT will receive support from exercise specialist, nursing support and dietician expertise alongside a supportive care 'app' with additional in-person or virtual cardiac rehabilitation support. DISCUSSION: To our knowledge, no research team is taking such a holistic, multidisciplinary approach to address the debilitating physiologic and psychological consequences of allo-BMT. We expect the findings to inform the optimal timing and patient preferences to develop studies examining risk-specific, individualized interventions (including exercise, pharmacotherapy, combination treatments) to reduce or prevent symptoms and dysfunction. We expect this innovative program to identify ways to benefit innumerable patients with hematologic and other malignancies. Ultimately, we hope to transform supportive care in hematopoietic stem cell transplantation.

trial registrationClinicaltrials.gov ID: NCT05579678.

Indexed as

Bone Marrow TransplantationHematologic NeoplasmsPrecision MedicineAdultHematopoietic Stem Cell TransplantationHumansTransplantation, HomologousAllogeneic bone marrow transplantCardiac rehabilitationCardiovascular diseasesCardiovascular risk factorsDeconditioningMalnutritionMRISarcopenia

Identifiers

PMID39875816
PMCPMC11773870

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.