Evidence map›Paper›PMID 39875997›Full record

ArticleBMC research notes2025

Ester derivatives of Dictyostelium differentiation-inducing factors exhibit antibacterial activity, possibly via a prodrug-like function.

Katsunori Takahashi, Haruhisa Kikuchi, Takehiro Nishimura, Hirotaka Ishigaki, Yusuke Miura, Ayuko Takahashi, Yuzuru Kubohara

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katsunori TakahashiDepartment of Medical Technology, Faculty of Health Science, Gunma Paz University, Takasaki, 370-0006, Japan.
Haruhisa KikuchiDivision of Natural Medicines, Faculty of Pharmacy, Keio University, Tokyo, 105-8512, Japan. halkiku@keio.jp.
Takehiro NishimuraDivision of Natural Medicines, Faculty of Pharmacy, Keio University, Tokyo, 105-8512, Japan.
Hirotaka IshigakiDepartment of Medical Technology, Faculty of Health Science, Gunma Paz University, Takasaki, 370-0006, Japan.
Yusuke MiuraDepartment of Medical Technology, Faculty of Health Science, Gunma Paz University, Takasaki, 370-0006, Japan.
Ayuko TakahashiDepartment of Medical Technology, Faculty of Health Science, Gunma Paz University, Takasaki, 370-0006, Japan.
Yuzuru KuboharaLaboratory of Health and Life Science, Graduate School of Health and Sports Science, Juntendo University, Inzai, 270-1695, Japan. ykuboha@juntendo.ac.jp.

Funding

Japan Society for the Promotion of Science 19K07139Japan Society for the Promotion of Science 22K11759
6 · The paper itself

Abstract

objectiveDictyostelium differentiation-inducing factors 1 and 3 [DIF-1 (1) and DIF-3 (2), respectively], along with their derivatives, such as Ph-DIF-1 (3) and Bu-DIF-3 (4), demonstrate antibacterial activity in vitro against Gram-positive bacteria, including methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant S. aureus (MRSA), vancomycin-sensitive Enterococcus faecalis (VSE), and vancomycin-resistant Enterococcus faecium [VRE (VanA)]. This study investigates the therapeutic potential of DIF compounds against these Gram-positive bacteria.

resultsIn vitro tests revealed that the antibacterial activity of 3 and 4 was lost in the presence of human serum albumin (HSA), suggesting that HSA might inhibit their effectiveness. Further evaluation of less hydrophobic derivatives, DIF-1-NH

Indexed as

Anti-Bacterial AgentsDictyosteliumEstersHexanonesProdrugsEnterococcus faecalisEnterococcus faeciumHumansHydrocarbons, ChlorinatedMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsStaphylococcus aureus1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanoneAnti-Bacterial AgentsDifferentiation-inducing factor-1, DictyosteliumEstersHexanonesHydrocarbons, ChlorinatedProdrugsAntibacterial agentDictyostelium discoideumMethicillin-resistant Staphylococcus aureusVancomycin-resistant Enterococcus faecium

Identifiers

PMID39875997
PMCPMC11776220

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.