Article in Archives of endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
17 authors.
Maria Teresa De SibioUniversidade Estadual Paulista Faculdade de Medicina de Botucatu BotucatuSP Brasil Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, Botucatu, SP, Brasil.ORCID https://orcid.org/0000-0001-5674-3514
Fernanda Cristina Fontes MorettoUniversidade Estadual Paulista Faculdade de Medicina de Botucatu BotucatuSP Brasil Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, Botucatu, SP, Brasil.ORCID https://orcid.org/0000-0003-3038-3068
Regiane Marques Castro OlimpioUniversidade Estadual Paulista Faculdade de Medicina de Botucatu BotucatuSP Brasil Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, Botucatu, SP, Brasil.ORCID https://orcid.org/0000-0002-4415-4744
Miriane de OliveiraUniversidade Estadual Paulista Faculdade de Medicina de Botucatu BotucatuSP Brasil Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, Botucatu, SP, Brasil.ORCID https://orcid.org/0000-0002-7003-667X
Lucas Solla MathiasUniversidade Estadual Paulista Faculdade de Medicina de Botucatu BotucatuSP Brasil Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, Botucatu, SP, Brasil.ORCID https://orcid.org/0000-0002-1415-9536
Vinícius Vigliazzi PeghinelliUniversidade Estadual Paulista Faculdade de Medicina de Botucatu BotucatuSP Brasil Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, Botucatu, SP, Brasil.ORCID https://orcid.org/0000-0002-4120-0880
Helena Paim TilliUniversidade Estadual Paulista Faculdade de Medicina de Botucatu BotucatuSP Brasil Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, Botucatu, SP, Brasil.ORCID https://orcid.org/0000-0002-8762-5999
Bianca Mariani GonçalvesUniversidade Estadual Paulista Faculdade de Medicina de Botucatu BotucatuSP Brasil Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, Botucatu, SP, Brasil.ORCID https://orcid.org/0000-0001-9054-9125
Dariane Beatriz Marino CardosoUniversidade Estadual Paulista Faculdade de Medicina de Botucatu BotucatuSP Brasil Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, Botucatu, SP, Brasil.ORCID https://orcid.org/0000-0002-8086-0347
Larissa Silva Dall AquaUniversidade Estadual Paulista Faculdade de Medicina de Botucatu BotucatuSP Brasil Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, Botucatu, SP, Brasil.ORCID https://orcid.org/0009-0009-4463-4025
Igor de Carvalho DepraUniversidade Estadual Paulista Faculdade de Medicina de Botucatu BotucatuSP Brasil Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, Botucatu, SP, Brasil.ORCID https://orcid.org/0000-0002-8093-8343
Mariana Menezes LourençoUniversidade Estadual Paulista Faculdade de Medicina de Botucatu BotucatuSP Brasil Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, Botucatu, SP, Brasil.ORCID https://orcid.org/0000-0002-1162-4404
Aline Carbonera LuvizonUniversidade Estadual Paulista Faculdade de Medicina de Botucatu BotucatuSP Brasil Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, Botucatu, SP, Brasil.ORCID https://orcid.org/0009-0008-8424-6441
Paula de Oliveira Montandon HokamaUniversidade Estadual Paulista Faculdade de Medicina de Botucatu BotucatuSP Brasil Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, Botucatu, SP, Brasil.ORCID https://orcid.org/0000-0003-3474-4422
Maria Tereza NunesUniversidade de São Paulo Instituto de Ciências Biomédicas São PauloSP Brasil Universidade de São Paulo, Instituto de Ciências Biomédicas, São Paulo, SP, Brasil.ORCID https://orcid.org/0000-0003-3375-4020
Marna Eliana SakalemUniversidade Estadual de Londrina Departamento de Anatomia LondrinaPR Brasil Departamento de Anatomia, Universidade Estadual de Londrina, Londrina, PR, Brasil.ORCID https://orcid.org/0000-0002-3143-4093
Célia Regina NogueiraUniversidade Estadual Paulista Faculdade de Medicina de Botucatu BotucatuSP Brasil Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, Botucatu, SP, Brasil.ORCID https://orcid.org/0000-0002-4014-0660
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
Objective: Considering that the αvβ3 integrin plays an important role in tumor metastasis, this study investigated the involvement of these pathways in mediating the triiodothyronine (T3) effects on amphiregulin ( Materials and methods: We treated MCF-7 cells with T3 (10 nM) for 1 hour in the presence or absence of inhibitors for αvβ3 integrin (RGD peptide), MAPK (PD98059), PI3K (LY294002), and protein synthesis (cycloheximide [CHX]). A control group (C) received no T3 or inhibitors. Analyses of mRNA and protein expression were done using RT-qPCR and Western blot, respectively. Results: We observed that T3 increased Conclusion: The identification that T3 acts through this signaling pathway holds considerable potential for clinical application, as it could lead to the development of specific drugs to block it.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Triiodothyronine (T3) increases the expression of the amphiregulin (AREG) oncogene by activating extranuclear pathways in MCF-7 breast cancer cells. · full record | Socratic