Evidence map›Paper›PMID 39877097›Full record

ArticleResearch square2025

Pro-cognitive restoration of experience-dependent parvalbumin inhibitory neuron plasticity in neurodevelopmental disorders.

Yu-Tzu Shih, Jason Bondoc Alipio, Zin-Juan Klaft, Nathaniel Green, Lai Ping Wong, Ruslan Sadreyev, Jung Ho Hyun, Chris Dulla, Amar Sahay

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Yu-Tzu ShihCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Jason Bondoc AlipioCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Zin-Juan KlaftDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA, USA.
Nathaniel GreenCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Lai Ping WongDepartment of Molecular Biology. Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Ruslan SadreyevDepartment of Molecular Biology. Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Jung Ho HyunDepartment of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology, Daegu, South Korea.ORCID https://orcid.org/0000-0003-0185-5943
Chris DullaDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA, USA.ORCID https://orcid.org/0000-0002-6560-6535
Amar SahayCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-0677-1693

Funding

Targeting neurogenesis-inhibition coupling to improve memory in aging\Diversity SupplementR01AG076612 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Amar Sahay · 2022 to 2026
$3.8M
Voltage Imaging of Astrocyte-Neuron InteractionsR01NS113499 · NINDS · TUFTS UNIVERSITY BOSTON · PI DULLA, CHRIS G · 2019 to 2023
$3.7M
Contributions of hippocampal oxytocin receptors to social recognitionR01MH111729 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI SAHAY, AMAR · 2018 to 2022
$2.4M
Hippocampal synaptic and circuit mechanisms mediating Dyrk1a functions in social cognitionR01MH131652 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI Amar Sahay · 2023 to 2026
$2.4M
Targeting Alternative Splicing of Sodium Channels to Treat Pediatric Developmental Epileptic EncephalopathiesR01NS139468 · NINDS · TUFTS UNIVERSITY MEDFORD · PI CHRISTOPHER B BURGE, Chris G Dulla · 2024 to 2026
$1.8M
NIA NIH HHS R01 AG076612NIMH NIH HHS R01 MH111729NIMH NIH HHS R01 MH131652NINDS NIH HHS R01 NS113499NINDS NIH HHS R01 NS139468
6 · The paper itself

Abstract

The hippocampus forms memories of our experiences by registering processed sensory information in coactive populations of excitatory principal cells or ensembles

Identifiers

PMID39877097
PMCPMC11774442

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.