Evidence map›Paper›PMID 39877389›Full record

ArticleFrontiers in pharmacology2024

Multi-target regulatory effects of rhaponticin in a rat model of hepatic fibrosis revealed by non-targeted metabolomics.

Min Yang, Dihua Jiang, Longfei Huang, Tao Zhang, Wenfen Guo, Wenyan Lin, Jiali Zhao, Yunsheng Wei, Lang Peng, Yong-Jia Hao and 1 more

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Min YangSchool of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Dihua JiangSchool of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Longfei HuangSchool of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Tao ZhangSchool of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Wenfen GuoSchool of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Wenyan LinSchool of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Jiali ZhaoSchool of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Yunsheng WeiSchool of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Lang PengSchool of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Yong-Jia HaoSchool of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Ying ZhouSchool of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Hepatic fibrosis (HF), a progressive chronic liver disease, is a serious threat to global public health. The lack of preventive and therapeutic strategies has created an urgent need for effective anti-fibrosis agents. There is growing evidence that natural products might provide safe and effective interventions for HF. Among them, rhaponticin (RHA), a stilbenoid glucoside natural product isolated from medicinal plants of Methods: Herein, we investigated the effects of RHA against HF on the carbon tetrachloride (CCl Results and discussion: The results showed that RHA improved liver functions and histopathological features in the liver of CCl

Indexed as

hepatic fibrosismetabolomicmolecular mechanismrhaponticintraditional Chinese medicine

Identifiers

PMID39877389
PMCPMC11772292

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.