ArticleIJID regions2025
Co-infection of human papillomavirus genotypes and Epstein-Barr virus in tumors of the oral cavity and oropharynx: a retrospective study in Northeastern Mexico.
Article in IJID regions, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Oncogenic viruses and their role in oral cavity and oropharyngeal squamous cell carcinoma: a systematic review.Frontiers in oncology · 2026Review
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: This study aimed to determine the prevalence and genotyping of human papillomavirus (HPV) and to assess co-infection with Epstein-Barr virus (EBV) in oral cavity and oropharyngeal cancers (OC and OPC) specimens from patients at a tertiary care hospital in Northeastern Mexico. Methods: Formalin-fixed and paraffin-embedded tumor specimens from 41 patients with OC and OPC were evaluated. HPV detection and genotyping were performed using the Ampliquality HPV-Type Express kit. EBV DNA detection was carried out by real-time quantitative polymerase chain reaction. Results: HPV DNA was detected in 14 (34.1%) specimens, with a higher prevalence in OC (78.6%) compared with OPC (21.4%). HPV-16 was the most frequently identified genotype (92.9%), found as a single infection in 53.8% of cases and co-infection with other genotypes in 46.2%. EBV DNA was detected in six (14.6%) specimens, with OC being the most common site. Co-infection with HPV and EBV was observed in only one case. Statistical significance was found between HPV infection and smoking history ( Conclusions: Our results reveal a higher prevalence of HPV infection in OC compared with OPC, with HPV-16 being the predominant genotype. HPV-positive cases were predominantly found in older male patients. Thus, expanding HPV vaccination to broader populations could potentially impact cancer incidence. EBV co-infection with HPV was infrequent, and further research is needed to fully understand the role of these viruses in OC and OPC development.
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