Evidence map›Paper›PMID 39877906›Full record

ArticleiScience2025

Select microbial metabolites in the small intestinal lumen regulate vagal activity via receptor-mediated signaling.

Kelly G Jameson, Sabeen A Kazmi, Takahiro E Ohara, Celine Son, Kristie B Yu, Donya Mazdeyasnan, Emma Leshan, Helen E Vuong, Jorge Paramo, Arlene Lopez-Romero and 3 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The critical role of gut-brain signalling in eating behaviour and obesity.Nature reviews. Gastroenterology & hepatology · 2026
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  8. Vagal GABAergic signaling in autonomic control of cardiometabolic function.American journal of physiology. Cell physiology · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Kelly G JamesonDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Sabeen A KazmiDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Takahiro E OharaDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Celine SonDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Kristie B YuDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Donya MazdeyasnanDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Emma LeshanDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Helen E VuongDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jorge ParamoUCLA Goodman-Luskin Microbiome Center, Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine, Los Angeles, CA 90095, USA.
Arlene Lopez-RomeroUCLA Goodman-Luskin Microbiome Center, Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine, Los Angeles, CA 90095, USA.
Long YangDepartment of Neurobiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Felix E SchweizerDepartment of Neurobiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Elaine Y HsiaoDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008042 · UNIVERSITY OF CALIFORNIA LOS ANGELES · 1985 to 2005
$6.0M
Dissecting Microbiota-Gut-Brain Interactions for the Anti-Seizure Effects of the Ketogenic DietR01NS115537 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Elaine Hsiao · 2022 to 2024
$903k
NIGMS NIH HHS T32 GM008042NINDS NIH HHS R01 NS115537
6 · The paper itself

Abstract

The vagus nerve is proposed to enable communication between the gut microbiome and the brain, but activity-based evidence is lacking. We find that mice reared germ-free exhibit decreased vagal tone relative to colonized controls, which is reversed via microbiota restoration. Perfusing antibiotics into the small intestines of conventional mice, but not germ-free mice, acutely decreases vagal activity which is restored upon re-perfusion with intestinal filtrates from conventional, but not germ-free, mice. Microbiome-dependent short-chain fatty acids, bile acids, and 3-indoxyl sulfate indirectly stimulate vagal activity in a receptor-dependent manner. Serial perfusion of each metabolite class activates both shared and distinct neuronal subsets with varied response kinetics. Metabolite-induced and receptor-dependent increases in vagal activity correspond with the activation of brainstem neurons. Results from this study reveal that the gut microbiome regulates select metabolites in the intestinal lumen that differentially activate vagal afferent neurons, thereby enabling the microbial modulation of chemosensory signals for gut-brain communication.

Indexed as

MicrobiomeNeuroscience

Identifiers

PMID39877906
PMCPMC11772968

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.