Evidence map›Paper›PMID 39878812›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Tinosinenside A inhibits neuroinflammation and protects HT22 cells by suppressing the TLR4/NF-κB/NLRP3 signaling pathway in BV2 cells.

Yongyan Xie, Yinfang Qin, Jingjing Wang, Ziwei Xu, Liping Chen, Yunxia Kuang, Ruwei Yang, Liping Huang

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yongyan XieSchool of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang, China.
Yinfang QinSchool of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang, China.
Jingjing WangSchool of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang, China.
Ziwei XuSchool of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang, China.
Liping ChenSchool of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang, China.
Yunxia KuangSchool of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang, China.
Ruwei YangSchool of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang, China.
Liping HuangSchool of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang, China. jxnchlp@163.com.

Funding

Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine 2024SSY07111the Development Plan of School-level Science and Technology Innovation Team of Jiangxi University of Chinese Medicine CXTD22007the National Natural Science Foundation of China 82060759The Pharmacy first-class specialty construction funds in 14th Five-Year Plan Period of Jiangxi Province, the College Students' Innovation and Entrepreneurship Training Program of Jiangxi University of Chinese Medicine 202410412166
6 · The paper itself

Abstract

Microglia-mediated neuroinflammation plays a crucial role in Alzheimer's disease (AD). Tinosinenside A (Tis A) is a novel sesquiterpene glycoside isolated from the dried rattan stem of Tinospora sinensis (Lour.) Merr. Tis A exhibited anti-inflammatory and neuroprotective activities in vitro. However, the mechanism underlying the inhibition of neuroinflammation and protection of nerve cells remains obscure. This study used lipopolysaccharide (LPS)-induced inflammatory response in BV2 cells to simulate a neuroinflammatory model and used Aβ

Indexed as

Anti-Inflammatory AgentsNeuroinflammatory DiseasesNeuroprotective AgentsNLR Family, Pyrin Domain-Containing 3 ProteinSesquiterpenesToll-Like Receptor 4Amyloid beta-PeptidesAnimalsCell LineCell SurvivalLipopolysaccharidesMiceMicrogliaNF-kappa BPeptide FragmentsSignal TransductionAmyloid beta-Peptidesamyloid beta-protein (1-42)Anti-Inflammatory AgentsLipopolysaccharidesNeuroprotective AgentsNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mousePeptide FragmentsSesquiterpenesTlr4 protein, mouseToll-Like Receptor 4MicrogliaNeuroinflammationTinosinenside ATLR4/NF-κB/NLRP3

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.