Evidence map›Paper›PMID 39879855›Full record

ArticleDNA repair2025

Small-molecule activator of SMUG1 enhances repair of pyrimidine lesions in DNA.

Yixuan Gao, Lisa McPherson, Shanthi Adimoolam, Samyuktha Suresh, David L Wilson, Ishani Das, Elizabeth R Park, Christine S C Ng, Yong Woong Jun, James M Ford and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in DNA repair, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yixuan GaoDepartment of Chemistry and Stanford University, Stanford, CA 94305, United States.
Lisa McPhersonDepartment of Medicine, Stanford University, Stanford, CA 94305, United States.
Shanthi AdimoolamDepartment of Medicine, Stanford University, Stanford, CA 94305, United States.
Samyuktha SureshDepartment of Medicine, Stanford University, Stanford, CA 94305, United States.
David L WilsonDepartment of Chemistry and Stanford University, Stanford, CA 94305, United States.
Ishani DasDepartment of Medicine, Stanford University, Stanford, CA 94305, United States.
Elizabeth R ParkDepartment of Chemistry and Stanford University, Stanford, CA 94305, United States.
Christine S C NgDepartment of Chemistry and Stanford University, Stanford, CA 94305, United States.
Yong Woong JunDepartment of Chemistry and Stanford University, Stanford, CA 94305, United States.
James M FordDepartment of Medicine, Stanford University, Stanford, CA 94305, United States.
Eric T KoolDepartment of Chemistry and Stanford University, Stanford, CA 94305, United States. Electronic address: kool@stanford.edu.

Funding

Measuring and Modulating Oxidative DNA Damage Surveillance PathwaysR01CA217809 · NCI · STANFORD UNIVERSITY · PI KOOL, ERIC T. · 2017 to 2024
$3.7M
Graduate Training Program in BiotechnologyT32GM141819 · NIGMS · STANFORD UNIVERSITY · PI Eric Andrew Appel, Fan Yang · 2021 to 2026
$1.9M
Stanford Chem-H Chemistry/Biology Interface Predoctoral Training ProgramT32GM120007 · NIGMS · STANFORD UNIVERSITY · PI BERTOZZI, CAROLYN · 2016 to 2020
$1.2M
500 MHz NMR Spectrometer System with High Sensitivity Cryoprobe and Automated Sample Changer for Biochemical ResearchS10OD028697 · OD · STANFORD UNIVERSITY · PI BURNS, NOAH ZACHARY · 2020 to 2020
$709k
NCI NIH HHS R01 CA217809NIGMS NIH HHS T32 GM120007NIGMS NIH HHS T32 GM141819NIH HHS S10 OD028697
6 · The paper itself

Abstract

A potentially promising approach to targeted cancer prevention in genetically at-risk populations is the pharmacological upregulation of DNA repair pathways. SMUG1 is a base excision repair enzyme that ameliorates adverse genotoxic and mutagenic effects of hydrolytic and oxidative damage to pyrimidines. Here we describe the discovery and initial cellular activity of a small-molecule activator of SMUG1. Screening of a kinase inhibitor library and iterative rounds of structure-activity relationship studies produced compound 40 (SU0547), which activates SMUG1 by as much as 350 ± 60 % in vitro at 100 nM, with an AC

Indexed as

DNADNA DamageDNA RepairPyrimidinesSmall Molecule LibrariesCell Line, TumorHumansStructure-Activity RelationshipDNApyrimidinePyrimidinesSmall Molecule Libraries5-hydroxymethyl-2’-deoxyuridineBase excision repairGenomic uracilMedicinal chemistrySmall molecule activatorSMUG1

Identifiers

PMID39879855
PMCPMC11846699

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.