ArticleThe Journal of nutrition2025
Dietary Carbohydrate Quality Is Associated with Epigenetic Age Acceleration: a Cross-Sectional Study of the CARDIA Cohort.
Article in The Journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Dietary intake and epigenetic aging in an African population: food groups, dietary patterns, and plant-based diets in the RODAM study.BMC medicine · 2026Article
- Chronobiology-Driven Anti-Aging Strategies for Enhancing Dentists' Occupational Health and Quality of Life: A Narrative Review.Healthcare (Basel, Switzerland) · 2026Review
- Nutrition and longevity - diet in centenarians.Journal of translational medicine · 2026Review
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Authors and funding
9 authors.
Funding
Abstract
backgroundDietary intake is one lifestyle factor that is expected to impact gene expression by altering DNA methylation (DNAm), thus affecting epigenetic aging. Studies on the association between quality of carbohydrates and epigenetic age acceleration (EAA) are scarce despite the evidence that quality may be more important than amount of carbohydrates consumed.
objectivesWe aimed to identify the cross-sectional associations of carbohydrate quality and fiber-rich food score with EAA in the Coronary Artery Risk Development in Young Adults (CARDIA) study.
methodsTrained interviewers administered the CARDIA Diet History to obtain dietary intake at examination year 20. EAA measures, PhenoAge acceleration (PhenoAA) and GrimAge acceleration (GrimAA), were generated based on epigenetic age estimates calculated using DNAm profiling data from fasting blood samples at examination years 20, 25, and 30. Linear mixed-effects regression models were used to evaluate the association of carbohydrate quality, defined using carbohydrate:fiber ratio, and fiber-rich food score with EAA measures.
resultsAfter adjusting for demographic and lifestyle factors, quartiles of carbohydrate quality (defined using carbohydrate:fiber ratio) were inversely associated with PhenoAA and GrimAA; the highest carbohydrate quality quartile showing a difference (standard error [SE]) of -1.19 (0.2) y for PhenoAA (P-trend < 0.001) and -1.20 (0.1) y for GrimAA (P-trend < 0.001) compared with the lowest carbohydrate quality quartile. Similarly, quartiles of fiber-rich food score (created based on daily intakes of whole grains, fruit, vegetables, nuts, and legumes) were inversely associated with PhenoAA and GrimAA; the highest quartile showing a difference (SE) of -1.06 (0.2) y for PhenoAA (P-trend = 0.002) and -1.31 (0.2) y for GrimAA (P-trend < 0.001) compared with the lowest quartile.
conclusionsOur findings suggest that consuming a high carbohydrate quality diet and a dietary pattern composed of fiber-rich foods is cross-sectionally associated with slower biological aging.
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