Evidence map›Paper›PMID 39880384›Full record

ArticleACS applied materials & interfaces2025

Wireless Stimulation of Barium Titanate@PEDOT Nanoparticles Toward Bioelectrical Modulation in Cancer.

Catarina Franco Jones, Marta S Carvalho, Akhil Jain, Paula Rodriguez-Lejarraga, Filipa Pires, Jorge Morgado, Senentxu Lanceros-Mendez, Frederico Castelo Ferreira, Teresa Esteves, Paola Sanjuan-Alberte

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Catarina Franco JonesDepartment of Bioengineering and iBB - Institute of Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, Lisbon 1049-001, Portugal.
Marta S CarvalhoDepartment of Bioengineering and iBB - Institute of Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, Lisbon 1049-001, Portugal.ORCID 0000-0003-1026-1995
Akhil JainDivision of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester M13 9PT, U.K.ORCID 0000-0003-2019-2030
Paula Rodriguez-LejarragaBasque Center for Materials, Applications and Nanostructures, UPV/EHU Science Park, BCMaterials, Leioa 48940, Spain.ORCID 0000-0001-5898-6149
Filipa PiresDepartment of Bioengineering and Instituto de Telecomunicações (IT), Instituto Superior Técnico, Universidade de Lisboa, Lisboa 1049-001, Portugal.
Jorge MorgadoDepartment of Bioengineering and Instituto de Telecomunicações (IT), Instituto Superior Técnico, Universidade de Lisboa, Lisboa 1049-001, Portugal.ORCID 0000-0002-0783-2657
Senentxu Lanceros-MendezBasque Center for Materials, Applications and Nanostructures, UPV/EHU Science Park, BCMaterials, Leioa 48940, Spain.ORCID 0000-0001-6791-7620
Frederico Castelo FerreiraDepartment of Bioengineering and iBB - Institute of Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, Lisbon 1049-001, Portugal.
Teresa EstevesDepartment of Bioengineering and iBB - Institute of Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, Lisbon 1049-001, Portugal.ORCID 0000-0003-0440-3619
Paola Sanjuan-AlberteDepartment of Bioengineering and iBB - Institute of Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, Lisbon 1049-001, Portugal.ORCID 0000-0002-2079-2864

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer cells possess distinct bioelectrical properties, yet therapies leveraging these characteristics remain underexplored. Herein, we introduce an innovative nanobioelectronic system combining a piezoelectric barium titanate nanoparticle core with a conducting poly(3,4-ethylenedioxythiophene) shell (BTO@PEDOT NPs), designed to modulate cancer cell bioelectricity through noninvasive, wireless stimulation. Our hypothesis is that acting as nanoantennas, BTO@PEDOT NPs convert mechanical inputs provided by ultrasound (US) into electrical signals, capable of interfering with the bioelectronic circuitry of two human breast cancer cell lines, MCF-7 and MDA-MB-231. Upon US stimulation, the viability of MCF-7 and MDA-MB-231 cells treated with 200 μg mL

Indexed as

Barium CompoundsBreast NeoplasmsBridged Bicyclo Compounds, HeterocyclicNanoparticlesPolymersTitaniumWireless TechnologyCell Line, TumorCell SurvivalHumansMCF-7 CellsReactive Oxygen SpeciesBarium Compoundsbarium titanate(IV)Bridged Bicyclo Compounds, Heterocyclicpoly(3,4-ethylene dioxythiophene)PolymersReactive Oxygen SpeciesTitaniumbreast cancercancer bioelectricitymultifunctional nanoparticlesnanobioelectronicsultrasound stimulationwireless stimulation

Identifiers

PMID39880384
PMCPMC11827599

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.