Evidence map›Paper›PMID 39880678›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Pmp2+ Schwann Cells Maintain the Survival of Large-Caliber Motor Axons.

Mikolaj M Kozlowski, Amy Strickland, Ana Morales Benitez, Robert E Schmidt, A Joseph Bloom, Jeffrey Milbrandt, Aaron DiAntonio

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. High-Fat Diet Disrupt Nerve Function by Targeting Schwann Cells.Journal of the peripheral nervous system : JPNS · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mikolaj M KozlowskiDepartments of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, 63110.
Amy StricklandGenetics, Washington University School of Medicine, St. Louis, Missouri, 63110.
Ana Morales BenitezDepartments of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, 63110.
Robert E SchmidtPathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, 63110.
A Joseph BloomGenetics, Washington University School of Medicine, St. Louis, Missouri, 63110.
Jeffrey MilbrandtGenetics, Washington University School of Medicine, St. Louis, Missouri, 63110 jmilbrandt@wustl.edu diantonio@wustl.edu.
Aaron DiAntonioDepartments of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, 63110 jmilbrandt@wustl.edu diantonio@wustl.edu.ORCID 0000-0002-7262-0968

Funding

Regulation of axonal degeneration by the DLK kinaseR37NS065053 · NINDS · WASHINGTON UNIVERSITY · PI Aaron Diantonio · 2020 to 2026
$4.3M
Jun O-GlcNAcylation Regulates Schwann Cell Injury ResponseR01NS105645 · NINDS · WASHINGTON UNIVERSITY · PI MILBRANDT, JEFFREY D · 2018 to 2021
$1.6M
NINDS NIH HHS R01 NS105645NINDS NIH HHS R37 NS065053
6 · The paper itself

Abstract

Neurodegenerative diseases of both the central and peripheral nervous system are characterized by selective neuronal vulnerability, i.e., pathology that affects particular types of neurons. While much of this cell type selectivity may be driven by intrinsic differences among the neuron subpopulations, neuron-extrinsic mechanisms such as the selective malfunction of glial support cells may also play a role. Recently, we identified a population of Schwann cells (SCs) expressing

Indexed as

AxonsMotor NeuronsMyelin ProteinsSchwann CellsAnimalsCell SurvivalFemaleMaleMiceMice, Inbred C57BLMice, TransgenicTamoxifenMyelin ProteinsTamoxifengliamotor axonsneuropathyPMP2Schwann cellsselective neuronal vulnerability

Identifiers

PMID39880678
PMCPMC11961402

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.