Observational studyCardiovascular diabetology2025
Association between triglyceride-glucose-body mass index and risk of aortic stenosis progression in patients with non-severe aortic stenosis: a retrospective cohort study.
Observational study in Cardiovascular diabetology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Association of triglyceride-glucose and obesity-derived indices with the risk of aortic stenosis among individuals in cardiovascular-kidney-metabolic syndrome stages 0-3: a prospective cohort study from the UK Biobank.Frontiers in endocrinology · 2026Article
- Association between cholesterol, high-density lipoprotein, and glucose index and risks of cardiovascular and all-cause mortality in patients with calcific aortic valve stenosis: the ARISTOTLE cohort study.Cardiovascular diabetology · 2025Observational
- Interaction between triglyceride-glucose-body mass index and age in coronary artery stenosis severity: a sex-stratified exploratory analysis.BMC cardiovascular disorders · 2025Article
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12 authors.
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Abstract
backgroundTriglyceride-glucose-BMI (TyG-BMI) index is a surrogate marker of insulin resistance and an important predictor of cardiovascular disease. However, the predictive value of TyG-BMI index in the progression of non-severe aortic stenosis (AS) is still unclear.
methodsThe present retrospective observational study was conducted using patient data from Aortic valve diseases RISk facTOr assessmenT andprognosis modeL construction (ARISTOTLE). A total of 190 patients were recruited from one-center. Patients were divided into two groups according to the cut-off value of TyG-BMI index (Ln[triglycerides (mg/dL)* glucose (mg/dL)/2]*BMI). Cox regression and restricted subgroup analysis were used to evaluate the association of TyG-BMI index and progression of non-severe AS.
resultsA total of 190 patients (mean age 72.52 ± 11.97 years, 51.58% male) were included in the study. During a median follow-up period of 27.48 months, 44 participants experienced disease progression. The cut-off of the TyG-BMI index is 239. After fully adjusting for confounding factors, high TyG-BMI index group was associated with a 2.219-fold higher risk of aortic stenosis progression (HR 2.219, 95%CI 1.086-4.537, p = 0.029).
conclusionTyG-BMI index was significantly associated with a higher risk of progression to non-severe AS. TyG-BMI index, as an effective alternative indicator of IR, can identify people at high risk of AS progression at an early stage of the disease, thereby improving the prognosis and reducing the socio-economic burden.
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