Evidence map›Paper›PMID 39882270›Full record

ArticleEuropean heart journal open2025

Characterization of LTBP2 mutation causing mitral valve prolapse.

Shoshi Shpitzen, Haim Rosen, Ayal Ben-Zvi, Karen Meir, Galina Levin, Amichay Gudgold, Shifra Ben Dor, Rebecca Haffner, Donna R Zwas, David Leibowitz and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. First quinquennium completed: highlights fromEuropean heart journal open · 2026
    Article
  2. Mechanisms of mitral valve development and disease.Frontiers in cardiovascular medicine · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Shoshi ShpitzenDepartment of Medicine, Cardiovascular Precision Medicine Center, Hadassah Hebrew University Medical Center, P.O. Box 12000, 9112001 Jerusalem, Israel.
Haim RosenThe Kuvin Center for the Study of Infectious and Tropical Diseases, Institute for Medical Research-Israel-Canada, Hebrew University-Hadassah Medical School, 9112001 Jerusalem, Israel.
Ayal Ben-ZviDevelopmental Biology and Cancer Research, Hadassah-Hebrew University Medical School, 9112001 Jerusalem, Israel.ORCID https://orcid.org/0000-0003-4012-7789
Karen MeirDepartment of Pathology, Hadassah Hebrew University Medical Center, P.O. Box 12000, 9112001 Jerusalem, Israel.
Galina LevinDepartment of Cardiology, Hadassah Hebrew University Medical Center, P.O. Box 12000, 9112001 Jerusalem, Israel.
Amichay GudgoldDepartment of Medicine, Cardiovascular Precision Medicine Center, Hadassah Hebrew University Medical Center, P.O. Box 12000, 9112001 Jerusalem, Israel.
Shifra Ben DorDepartment of Life Sciences Core Facilities, Weizmann Institute of Science, Herzl St 234, 7610001 Rehovot, Israel.ORCID https://orcid.org/0000-0001-9604-1939
Rebecca HaffnerDepartment of Veterinary Resources, Weizmann Institute of Science, Herzl St 234, 7610001 Rehovot, Israel.
Donna R ZwasDepartment of Cardiology, Hadassah Hebrew University Medical Center, P.O. Box 12000, 9112001 Jerusalem, Israel.
David LeibowitzDepartment of Cardiology, Hadassah Hebrew University Medical Center, P.O. Box 12000, 9112001 Jerusalem, Israel.
Susan A SlaugenhauptCenter for Genomic Medicine, Massachusetts General Hospital Research Institute, 185 Cambridge Street, Boston, MA 02114, USA.
Eyal BaninCenter for Retinal and Macular Degenerations, Department of Ophthalmology, Hadassah Hebrew University Medical Center, P.O. Box 12000, 911200120 Jerusalem, Israel.
Rotem MizrachiCenter for Retinal and Macular Degenerations, Department of Ophthalmology, Hadassah Hebrew University Medical Center, P.O. Box 12000, 911200120 Jerusalem, Israel.
Alexey ObolenskyCenter for Retinal and Macular Degenerations, Department of Ophthalmology, Hadassah Hebrew University Medical Center, P.O. Box 12000, 911200120 Jerusalem, Israel.
Robert A LevineCardiac Ultrasound Laboratory, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA.ORCID https://orcid.org/0000-0002-9484-8218
Dan GilonDepartment of Cardiology, Hadassah Hebrew University Medical Center, P.O. Box 12000, 9112001 Jerusalem, Israel.
Eran LeitersdorfDepartment of Medicine, Cardiovascular Precision Medicine Center, Hadassah Hebrew University Medical Center, P.O. Box 12000, 9112001 Jerusalem, Israel.
Idit TesslerDepartment of Medicine, Cardiovascular Precision Medicine Center, Hadassah Hebrew University Medical Center, P.O. Box 12000, 9112001 Jerusalem, Israel.ORCID https://orcid.org/0000-0002-3297-7022
Noga ReshefDepartment of Medicine, Cardiovascular Precision Medicine Center, Hadassah Hebrew University Medical Center, P.O. Box 12000, 9112001 Jerusalem, Israel.
Ronen DurstDepartment of Medicine, Cardiovascular Precision Medicine Center, Hadassah Hebrew University Medical Center, P.O. Box 12000, 9112001 Jerusalem, Israel.ORCID https://orcid.org/0000-0003-3559-1050

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Mitral valve prolapse (MVP) is a common valvular disorder associated with significant morbidity and mortality, with a strong genetic basis. This study aimed to identify a mutation in a family with MVP and to characterize the valve phenotype in LTBP2 knockout (KO) mice. Methods and results: Exome sequencing and segregation analysis were performed on a large family with MVP. Two mouse strains were generated: a complete KO of the Conclusion: We report a KO mouse strain with an

Indexed as

LTBP2Mitral valve prolapseMyxomatous valve

Identifiers

PMID39882270
PMCPMC11775471

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.