Article in Stroke, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
19 authors.
Reinier W P TackMcCance Center for Brain Health (R.W.P.T., B.Y.Q.T., J.R.S., S.P., T.N.K., S.D.S., J.R., E.M., C.D.A.), Massachusetts General Hospital, Boston.ORCID 0000-0003-3204-0309
Benjamin Y Q TanMcCance Center for Brain Health (R.W.P.T., B.Y.Q.T., J.R.S., S.P., T.N.K., S.D.S., J.R., E.M., C.D.A.), Massachusetts General Hospital, Boston.ORCID 0000-0003-1824-9077
Jasper R SenffMcCance Center for Brain Health (R.W.P.T., B.Y.Q.T., J.R.S., S.P., T.N.K., S.D.S., J.R., E.M., C.D.A.), Massachusetts General Hospital, Boston.ORCID 0009-0002-6540-480X
Savvina PrapiadouMcCance Center for Brain Health (R.W.P.T., B.Y.Q.T., J.R.S., S.P., T.N.K., S.D.S., J.R., E.M., C.D.A.), Massachusetts General Hospital, Boston.ORCID 0000-0001-7415-2566
Tamara N KimballMcCance Center for Brain Health (R.W.P.T., B.Y.Q.T., J.R.S., S.P., T.N.K., S.D.S., J.R., E.M., C.D.A.), Massachusetts General Hospital, Boston.ORCID 0000-0002-1107-0771
Shaan KhurshidCardiovascular Research Center (S.K., L.-C.W., S.G., C.R., P.T.E.), Massachusetts General Hospital, Boston.ORCID 0000-0002-2840-4539
Jeffrey M AshburnerDivision of General Internal Medicine (J.M.A.), Massachusetts General Hospital, Boston.ORCID 0000-0002-5600-3492
Sean J JurgensCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA (S.J.J.).ORCID 0000-0002-1605-9782
Sanjula D SinghMcCance Center for Brain Health (R.W.P.T., B.Y.Q.T., J.R.S., S.P., T.N.K., S.D.S., J.R., E.M., C.D.A.), Massachusetts General Hospital, Boston.
Lu-Chen WengCardiovascular Research Center (S.K., L.-C.W., S.G., C.R., P.T.E.), Massachusetts General Hospital, Boston.ORCID 0000-0003-1475-4930
Sophia GunnCardiovascular Research Center (S.K., L.-C.W., S.G., C.R., P.T.E.), Massachusetts General Hospital, Boston.ORCID 0000-0001-6451-050X
Carolina RoselliCardiovascular Research Center (S.K., L.-C.W., S.G., C.R., P.T.E.), Massachusetts General Hospital, Boston.ORCID 0000-0001-5267-6756
Kathryn L LunettaBiostatistics (S.G., K.L.L.), Boston University School of Public Health, MA.ORCID 0000-0002-9268-810X
Emelia J BenjaminDepartment of Medicine, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine, MA (E.J.B.).ORCID 0000-0003-4076-2336
Patrick T EllinorCardiovascular Research Center (S.K., L.-C.W., S.G., C.R., P.T.E.), Massachusetts General Hospital, Boston.ORCID 0000-0002-2067-0533
Jonathan RosandMcCance Center for Brain Health (R.W.P.T., B.Y.Q.T., J.R.S., S.P., T.N.K., S.D.S., J.R., E.M., C.D.A.), Massachusetts General Hospital, Boston.ORCID 0000-0002-1014-9138
Ernst MayerhoferMcCance Center for Brain Health (R.W.P.T., B.Y.Q.T., J.R.S., S.P., T.N.K., S.D.S., J.R., E.M., C.D.A.), Massachusetts General Hospital, Boston.ORCID 0000-0001-8902-4209
Steven A Lubitz *Center for Genomic Medicine (R.W.P.T., B.Y.Q.T., J.R.S., S.D.S., J.R., E.M., S.A.L.), Massachusetts General Hospital, Boston.ORCID 0000-0002-9599-4866
Christopher D Anderson *McCance Center for Brain Health (R.W.P.T., B.Y.Q.T., J.R.S., S.P., T.N.K., S.D.S., J.R., E.M., C.D.A.), Massachusetts General Hospital, Boston.ORCID 0000-0002-0053-2002
Funding
IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6M
Using Electrocardiogram Genetics to Inform Arrhythmia RiskR01HL157635 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS, MIRSHAHI, TOORAJ · 2022 to 2025
$2.9M
FHS-NEXT - Framingham Novel EXam using TechnologyR01HL141434 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., MCMANUS, DAVID D. · 2019 to 2022
$2.5M
Identifying primary care patients at increased risk of atrial fibrillation for screening interventionsK01HL148506 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ASHBURNER, JEFFREY M · 2019 to 2023
$887k
Electrocardiogram-based deep learning and decision analysis to improve atrial fibrillation risk estimationK23HL169839 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Shaan Khurshid · 2023 to 2026
$860k
American Heart Association-American Stroke Association 18SFRN34150007American Heart Association-American Stroke Association 23CDA1050571American Heart Association-American Stroke Association 812095American Heart Association-American Stroke Association 814721NHLBI NIH HHS K01 HL148506NHLBI NIH HHS K23 HL169839NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL141434NHLBI NIH HHS R01 HL157635
6 · The paper itself
Abstract
backgroundBecause treatment with anticoagulants can prevent recurrent strokes, identification of patients at risk for incident atrial fibrillation (AF) after stroke is crucial. We aimed to investigate whether the addition of AF polygenic risk scores (PRSs) to existing clinical risk predictors could improve prediction of AF after stroke.
methodsPatients diagnosed with ischemic stroke at the Massachusetts General Hospital between 2003 and 2017 were included. Clinical AF risk was estimated using the Recalibrated Cohorts for Heart and Aging Research in Genomic Epidemiology Atrial Fibrillation model, and genetic risk was estimated using a contemporary AF PRS from 1 093 050 variants. Patients were divided into clinical and genetic risk tertiles. Cox proportional hazards models at different follow-up windows were fit, and C indices and percentile-based net reclassification index were used to determine the improvement of clinical risk models with the addition of AF PRS.
resultsOf 1004 stroke survivors, 900 (90%) were non-Hispanic White, 413 (41%) were female, and the mean age was 67 (SD, 14) years. Of 1004 survivors, 239 (23.8%) had prevalent AF and 87 of 765 (11.4%) remaining patients developed incident AF during 5 years of follow-up. AF PRS was associated with greater risk of incident AF after stroke (hazard ratio, 1.21 [95% CI, 0.97-1.50] per 1-SD increase), although the association was not statistically significant. PRS improved discrimination in the first month (area under the curve, 0.78 [95% CI, 0.70-0.82] versus 0.71 [95% CI, 0.60-0.82];
conclusionsAddition of an AF PRS to clinical risk models may improve identification of individuals at risk of AF after stroke, particularly within the first month.
Indexed as
Atrial FibrillationIschemic StrokeMultifactorial InheritanceStrokeAgedAged, 80 and overFemaleGenetic Risk ScoreHumansMaleMiddle AgedRisk AssessmentRisk Factorsanticoagulantsarea under curveatrial fibrillationgenetic risk scorestroke
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Predicting Atrial Fibrillation After Stroke by Combining Polygenic Risk Scores and Clinical Features. · full record | Socratic