Evidence map›Paper›PMID 39883596›Full record

ReviewACS synthetic biology2025

Considerations for Domestication of Novel Strains of Filamentous Fungi.

Randi M Pullen, Stephen R Decker, Venkataramanan Subramanian, Meaghan J Adler, Alexander V Tobias, Matthew Perisin, Christian J Sund, Matthew D Servinsky, Mark T Kozlowski

Abstract readReview
In one paragraph

Review in ACS synthetic biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Randi M PullenDEVCOM Army Research Laboratory, 2800 Powder Mill Rd., Adelphi, Maryland 20783, United States.
Stephen R DeckerNational Renewable Energy Laboratory, 15013 Denver West Parkway, Golden, Colorado 80401, United States.
Venkataramanan SubramanianNational Renewable Energy Laboratory, 15013 Denver West Parkway, Golden, Colorado 80401, United States.
Meaghan J AdlerDEVCOM Army Research Laboratory, 2800 Powder Mill Rd., Adelphi, Maryland 20783, United States.
Alexander V TobiasDEVCOM Army Research Laboratory, 2800 Powder Mill Rd., Adelphi, Maryland 20783, United States.
Matthew PerisinDEVCOM Army Research Laboratory, 2800 Powder Mill Rd., Adelphi, Maryland 20783, United States.
Christian J SundDEVCOM Army Research Laboratory, 2800 Powder Mill Rd., Adelphi, Maryland 20783, United States.
Matthew D ServinskyDEVCOM Army Research Laboratory, 2800 Powder Mill Rd., Adelphi, Maryland 20783, United States.
Mark T KozlowskiDEVCOM Army Research Laboratory, 2800 Powder Mill Rd., Adelphi, Maryland 20783, United States.ORCID 0000-0003-4714-8697

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fungi, especially filamentous fungi, are a relatively understudied, biotechnologically useful resource with incredible potential for commercial applications. These multicellular eukaryotic organisms have long been exploited for their natural production of useful commodity chemicals and proteins such as enzymes used in starch processing, detergents, food and feed production, pulping and paper making and biofuels production. The ability of filamentous fungi to use a wide range of feedstocks is another key advantage. As chassis organisms, filamentous fungi can express cellular machinery, and metabolic and signal transduction pathways from both prokaryotic and eukaryotic origins. Their genomes abound with novel genetic elements and metabolic processes that can be harnessed for biotechnology applications. Synthetic biology tools are becoming inexpensive, modular, and expansive while systems biology is beginning to provide the level of understanding required to design increasingly complex synthetic systems. This review covers the challenges of working in filamentous fungi and offers a perspective on the approaches needed to exploit fungi as microbial cell factories.

Indexed as

FungiBiotechnologyGenome, FungalMetabolic EngineeringSynthetic Biologyfilamentous fungimicrobial cell factorymolecular biologysynthetic biology

Identifiers

PMID39883596
PMCPMC11852223

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.