Evidence map›Paper›PMID 39885510›Full record

Observational studyJournal of translational medicine2025

Multiomics unravels the complexity of male obesity: a prospective observational study.

Georgios E Papadakis, Lucie Favre, Yassine Zouaghi, Nathalie Vionnet, Nicolas J Niederländer, Michela Adamo, James S Acierno, Dassine Berdous, Alexia Boizot, Jenny Meylan and 17 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Georgios E PapadakisDepartment of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Avenue de la Sallaz 8, CH-1011, Lausanne, Switzerland.
Lucie Favre *Department of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Avenue de la Sallaz 8, CH-1011, Lausanne, Switzerland.
Yassine Zouaghi *Department of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Avenue de la Sallaz 8, CH-1011, Lausanne, Switzerland.
Nathalie VionnetDepartment of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Avenue de la Sallaz 8, CH-1011, Lausanne, Switzerland.
Nicolas J NiederländerDepartment of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Avenue de la Sallaz 8, CH-1011, Lausanne, Switzerland.
Michela AdamoDepartment of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Avenue de la Sallaz 8, CH-1011, Lausanne, Switzerland.
James S AciernoDepartment of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Avenue de la Sallaz 8, CH-1011, Lausanne, Switzerland.
Dassine BerdousDepartment of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Avenue de la Sallaz 8, CH-1011, Lausanne, Switzerland.
Alexia BoizotDepartment of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Avenue de la Sallaz 8, CH-1011, Lausanne, Switzerland.
Jenny MeylanDepartment of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Avenue de la Sallaz 8, CH-1011, Lausanne, Switzerland.
Julijana IvanisevicMetabolomics Platform, Faculty of Biology and Medicine, University of Lausanne, Rue du Bugnon 19, CH-1005, Lausanne, Switzerland.
Emmanuelle PaccouDepartment of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Avenue de la Sallaz 8, CH-1011, Lausanne, Switzerland.
Hector Gallart-AyalaMetabolomics Platform, Faculty of Biology and Medicine, University of Lausanne, Rue du Bugnon 19, CH-1005, Lausanne, Switzerland.
Tim ReynsDepartment of Clinical Chemistry, Ghent University Hospital, 9000, Ghent, Belgium.
Elise Van CaeneghemDepartment of Clinical Chemistry, Ghent University Hospital, 9000, Ghent, Belgium.
Bruno LapauwDepartment of Clinical Chemistry, Ghent University Hospital, 9000, Ghent, Belgium.
Jérôme PasquierCenter for Primary Care and Public Health, University of Lausanne, CH-1011, Lausanne, Switzerland.
Yasser AlemanDivision of Radio-Diagnostics and Interventional Radiology, Lausanne University Hospital, Rue du Bugnon 46, CH-1011, Lausanne, Switzerland.
Styliani MantziariFaculty of Biology and Medicine, University of Lausanne, Rue du Bugnon 21, CH-1005, Lausanne, Switzerland.
Olivier SalaminSwiss Laboratory for Doping Analyses, University Center of Legal Medicine, Lausanne University Hospital and University of Geneva, Chemin de La Vulliette 4, CH-1000, Lausanne, Switzerland.
Raul NicoliSwiss Laboratory for Doping Analyses, University Center of Legal Medicine, Lausanne University Hospital and University of Geneva, Chemin de La Vulliette 4, CH-1000, Lausanne, Switzerland.
Tiia KuuranneSwiss Laboratory for Doping Analyses, University Center of Legal Medicine, Lausanne University Hospital and University of Geneva, Chemin de La Vulliette 4, CH-1000, Lausanne, Switzerland.
Tom FiersDepartment of Clinical Chemistry, Ghent University Hospital, 9000, Ghent, Belgium.
Patric HagmannFaculty of Biology and Medicine, University of Lausanne, Rue du Bugnon 21, CH-1005, Lausanne, Switzerland.
Federico SantoniDepartment of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Avenue de la Sallaz 8, CH-1011, Lausanne, Switzerland.
Andrea MessinaDepartment of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Avenue de la Sallaz 8, CH-1011, Lausanne, Switzerland.
Nelly PitteloudDepartment of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Avenue de la Sallaz 8, CH-1011, Lausanne, Switzerland. nelly.pitteloud@chuv.ch.ORCID 0000-0003-0971-3237

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung #310030B_201275
6 · The paper itself

Abstract

backgroundObesity is associated with varying degrees of metabolic dysfunction. In this study, we aimed to discover markers of the severity of metabolic impairment in men with obesity via a multiomics approach.

methodsThirty-two morbidly men with obesity who were candidates for Roux-en-Y gastric bypass (RYGB) surgery were prospectively followed. Nine healthy adults served as controls. Deep phenotyping, including targeted metabolomics, transcriptomics, and brain magnetic resonance imaging (MRI), was performed.

resultsTestosterone emerged as a key contributor to phenotypic variability via principal component analysis and was therefore used to further categorize obese patients as having or not having hypogonadotropic hypogonadism (HH). Despite having comparable body mass indices, obese individuals with HH presented with worse metabolic defects than obese individuals without HH, including higher insulin resistance, as well as MRI signs of hypothalamic inflammation and a specific blood transcriptomics signature. The upregulated genes were involved mainly in inflammation, mitochondrial function, and protein translation. Integration of gene expression and clinical data revealed high FGF21 and low cortisol levels as the top markers correlated with the transcriptomic signature of metabolic risk. Following RYGB-induced substantial weight loss, testosterone levels markedly increased in both obese individuals with and without HH, challenging the current definition of hypogonadism. A longitudinal study in a subset of men with obesity following bariatric surgery revealed a unique FGF21 trajectory with a sharp peak at one month post-RYGB that correlated with metabolic and reproductive improvements.

conclusionsCombining clinical, biochemical, and molecular markers allows adequate stratification of metabolic risk in men with obesity and provides novel tools for personalized care.

Indexed as

MetabolomicsObesityAdultHumansHypogonadismMagnetic Resonance ImagingMaleMiddle AgedMultiomicsProspective StudiesTestosteroneTranscriptomeTestosteroneBariatric surgeryHypogonadismMale obesityMetabolic risk stratificationTranscriptomics

Identifiers

PMID39885510
PMCPMC11783726

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.