ArticleJournal of translational medicine2025
Association of pre- and post-diagnosis dietary total antioxidant capacity (TAC) and composite dietary antioxidant index (CDAI) with overall survival in patients with ovarian cancer: a prospective cohort study.
Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The Sleep Connection: Exploring the Role of Composite Dietary Antioxidant Index in Sleep Quality Based on NHANES 2007-2014.International journal of medical sciences · 2026Article
- Association of dietary intake patterns with treatment outcomes in late-stage pancreatic tumors.Frontiers in nutrition · 2026Article
- Composite dietary antioxidant index and risk of ischemic heart disease and stroke: insights from a UK Biobank large-scale cohort study.Frontiers in nutrition · 2026Article
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Authors and funding
19 authors.
Funding
Abstract
backgroundThe evidence on the relationship of dietary antioxidant nutrients with the survival of ovarian cancer (OC) remains scarce.
objectiveThis study aimed to investigate these associations in a prospective cohort of Chinese patients with OC.
methodsIn this prospective cohort study, patients with epithelial OC completed a food frequency questionnaire at diagnosis and 12 months post-diagnosis, and were followed from 2015 to 2023. Dietary total antioxidant capacity (TAC) and composite dietary antioxidant index (CDAI) were calculated based on specific antioxidant nutrients. We examined the associations of pre-diagnosis, post-diagnosis, and changes from pre-diagnosis to post-diagnosis in TAC, CDAI, and representative antioxidant nutrients with overall survival (OS) among patients with OC. Multivariable Cox proportional-hazards models were applied to calculate the hazard ratios (HR) and 95% confidence intervals (CI). Dose-response relationships were evaluated by restricted cubic splines.
resultsAmong the total 560 patients with OC, there were 211 (37.68%) deaths during a median follow-up of 44.40 (interquartile range: 26.97-61.37) months. High pre-diagnosis TAC (HR = 0.58; 95% CI 0.38-0.8) and vitamin C intake (HR
conclusionHigh pre- and post-diagnosis TAC, and post-diagnosis CDAI were associated with improved OC survival, suggesting that consistent high-intake of antioxidant-rich food may be beneficial for the prognosis of OC.
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