Evidence map›Paper›PMID 39885603›Full record

ArticleJournal of neuroinflammation2025

Associations between inflammation and striatal dopamine D2-receptor availability in aging.

Vanessa Crine, Goran Papenberg, Jarkko Johansson, Carl-Johan Boraxbekk, Anders Wåhlin, Ulman Lindenberger, Martin Lövdén, Katrine Riklund, Lars Bäckman, Lars Nyberg and 1 more

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In one paragraph

Article in Journal of neuroinflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. The role of dopamine decline, astrocyte reactivity and cerebral small-vessel disease in cognitive aging.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vanessa CrineDepartment of Medical and Translational Biology, Umeå university, Umeå, 901 87, Sweden.
Goran PapenbergAging Research Center, Karolinska Institute and Stockholm University, Stockholm, Sweden.
Jarkko JohanssonUmeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden.
Carl-Johan BoraxbekkUmeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden.
Anders WåhlinUmeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden.
Ulman LindenbergerCenter for Lifeorgdivision Psychology, Max Planck Institute for Human Development, Berlin, Germany.
Martin LövdénDepartment of Psychology, University of Gothenburg, Gothenburg, Sweden.
Katrine RiklundUmeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden.
Lars BäckmanAging Research Center, Karolinska Institute and Stockholm University, Stockholm, Sweden.
Lars NybergDepartment of Medical and Translational Biology, Umeå university, Umeå, 901 87, Sweden.
Nina KaralijaDepartment of Medical and Translational Biology, Umeå university, Umeå, 901 87, Sweden. nina.karalija@umu.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNormal brain aging is associated with dopamine decline, which has been linked to age-related cognitive decline. Factors underlying individual differences in dopamine integrity at older ages remain, however, unclear. Here we aimed at investigating: (i) whether inflammation is associated with levels and 5-year changes of in vivo dopamine D2-receptor (DRD2) availability, (ii) if DRD2-inflammation associations differ between men and women, and (iii) whether inflammation and cerebral small-vessel disease (white-matter lesions) serve as two independent predictors of DRD2 availability.

methodsAnalyses were performed in a sample of healthy adults > 60 years assessed at two measurement occasions separated by 5 years. At both occasions, DRD2 availability was estimated by

resultsIndividuals with higher DNA methylation scores at baseline showed reduced striatal DRD2 availability. An interaction was found between DNA methylation scores and sex in relation to striatal DRD2 availability, such that associations were found in men but not in women. DNA methylation scores at study entrance were not significantly associated with 5-year striatal DRD2 decline rates. No significant association was found between DNA methylation scores and white-matter lesions, but higher scores as well as higher lesion burden were independently associated with reduced striatal DRD2 availability in men.

conclusionsThese findings suggest negative associations between one proxy of inflammation and DRD2 availability in older adults, selectively for men who had higher DNA methylation scores. Future studies should investigate other inflammatory markers in relation to dopamine integrity.

Indexed as

AgingCorpus StriatumInflammationReceptors, Dopamine D2AgedAged, 80 and overDNA MethylationFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPositron-Emission TomographyDRD2 protein, humanReceptors, Dopamine D2AgingDopamine D2-receptor availabilityInflammationPositron emission tomographyWhite-matter lesions

Identifiers

PMID39885603
PMCPMC11783874

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.