ArticleFrontiers in veterinary science2024
Innovative surgical and stress-stimulated rat model of ligamentum flavum hypertrophy.
Article in Frontiers in veterinary science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Ligamentum flavum hypertrophy animal models: methodological trade-offs and future directions.Frontiers in veterinary science · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and purpose: Animal models of LFH are still in the exploratory stage. This study aimed to establish a reliable, efficient, and economical model of LFH in rats for the study of human ligamentum flavum (LF) pathological mechanisms, drug screening, development, improvement of surgical treatment, disease prevention, and other aspects. Methods and materials: Forty rats were divided into an experimental group and a sham group of 20 rats. The experimental group ( Results: MRI results showed that the LF in the experimental group was significantly thicker than that in the sham group. Masson staining results indicated that LF thickness, collagen fiber area, and collagen volume fraction (CVF) were significantly higher in the experimental group than in the sham group. IHC and WB showed that the expression of TGF-β1, COL1, and IL-1β in the LF of the experimental group was significantly higher than that in the LF of sham group. Conclusion: Through innovative surgical intervention combined with stress stimulation, a relatively reliable, efficient, and convenient rat LFH model was established.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.