ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Association of arterial structure and function with incident cardiovascular diseases and cognitive decline.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Integrative Observational and Genetic Evidence From the UK Biobank Supports Carotid Intima-Media Thickness as a Window Into Cardiac Remodeling.Journal of the American Heart Association · 2026Observational
- Carotid stiffness quantified through shear wave elastography and pulse wave velocity by ultrafast ultrasound for assessing cardiovascular risk.Quantitative imaging in medicine and surgery · 2026Article
- Carotid intima-media thickness in relation to primary open-angle glaucoma: epidemiological and structural evidence from a cross-sectional study.BMJ open ophthalmology · 2026Article
- Biological aging mediates and frailty modifies the associations of arterial stiffness with incident probable sarcopenia and sarcopenia: a prospective cohort study of UK biobank.Frontiers in public health · 2026Article
- The heart-brain axis: unraveling the interconnections between cardiovascular and Alzheimer's diseases.Frontiers in cardiovascular medicine · 2025Review
- Cognitive decline and carotid intima-media thickness: The presumed association of two vaguely defined clinical "entities".Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Association of arterial structure and function with incident cardiovascular diseases and cognitive decline.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: We examined the associations of carotid intima-media thickness (CIMT), arterial stiffness index (ASI), and pulse pressure (PP) with cerebrovascular disease, cognitive function and decline, and incident cardiovascular diseases (CVD) and dementia in the UK Biobank cohort. Methods: The study consisted of 42,711 participants (mean age 64.2 years) with brain magnetic resonance imaging (MRI), vascular assessments, and cognitive testing. Cerebrovascular disease markers included white matter hyperintensities (WMH) and brain volumes. CIMT, ASI, and PP were measured using carotid ultrasound, photoplethysmography, and blood pressure, respectively. General cognitive ability ( Results: Elevated CIMT, ASI, and PP were associated with increased WMH volume (WMHV). Increased PP was independently associated with poorer numeric memory ( Discussion: CIMT had the most robust associations with WMHV, incident CVD, and dementia, suggesting its utility as an alternative endpoint. Highlights: Effects of arterial stiffness on cognition, dementia, and CVD.Structural vascular parameters included CIMT.Functional properties included ASI and PP.CIMT, ASI, and PP were positively associated with WMHV.CIMT had the greatest associations with incident CVD and dementia.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.