ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Age-disproportionate atrophy in Alzheimer's disease and Parkinson's disease spectra.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Whole-brain histogram analysis and top 20% gray and white matter ratio of amyloid positron emission tomography: A comparison with the centiloid scale.Annals of nuclear medicine · 2026Article
- Association of imaging-defined brain age with disease severity and adverse outcomes in CADASIL.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Regional brain age is decreased in children with sickle cell anemia.Blood advances · 2026Article
- Brain age gap as predictor of disease progression in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Brain age prediction from MRI scans in neurodegenerative diseases.Current opinion in neurology · 2025Review
- Assessment of Cognitive Function via Biomarkers in Japanese Patients With Chronic Heart Failure Treated With Angiotensin-Receptor-Neprilysin Inhibitor.Circulation reports · 2025Article
- Age-disproportionate atrophy in Alzheimer's disease and Parkinson's disease spectra.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
17 authors.
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Abstract
introductionBrain age gap (BAG), defined as the difference between MRI-predicted 'brain age' and chronological age, can capture information underlying various neurological disorders. We investigated the pathophysiological significance of the BAG across neurodegenerative disorders.
methodsWe developed a brain age estimator using structural MRIs of healthy-aged individuals from one cohort study. Subsequently, we applied this estimator to people with Alzheimer's disease spectra (AD) and Parkinson's disease (PD) from another cohort study. We investigated brain sources responsible for BAGs among these groups.
resultsBoth AD and PD exhibited a positive BAG. Brain sources showed overlapping, yet partially segregated, neuromorphological differences between these groups. Furthermore, employing with t-distributed stochastic neighbor embedding on the brain sources, we subclassified PD into two groups with and without cognitive impairment. DISCUSSION: Our findings suggest that brain age estimation becomes a clinically relevant method for finely stratifying neurodegenerative disorders. Highlights: Brain age estimated from structure MRI data was greater than chronological age in patients with Alzheimer's disease/mild cognitive impairment or Parkinson's disease.Brain regions attributed to brain age estimation were located mainly in the fronto-temporo-parietal cortices but not in the motor cortex or subcortical regions.Brain sources responsible for the brain age gaps revealed roughly overlapping, yet partially segregated, neuromorphological differences between participants with Alzheimer's disease/mild cognitive impairment and Parkinson's disease.Participants with Parkinson's disease were subclassified into two groups (with and without cognitive impairment) based on brain sources responsible for the brain age gaps.
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