ArticleBMJ oncology2023
Global trends in incidence, death, burden and risk factors of early-onset cancer from 1990 to 2019.
Article in BMJ oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 182 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
182 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Fertility preservation access among female adolescents and young adults with cancer: A systematic review.Cancer · 2026Pooled it
- "I didn't really fit into any boxes": understanding the experiences of women affected by cancer in pregnancy and up to one-year postpartum-a mixed-method systematic review.Journal of cancer survivorship : research and practice · 2026Pooled it
- Parenting concerns among patients with cancer: a qualitative meta-synthesis.Frontiers in psychology · 2026Pooled it
- Towards a better understanding of brief lifestyle interventions in noncommunicable diseases: a concept analysis.BMC public health · 2025Pooled it
- Impact of Lifestyle Modifications on Cancer Mortality: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Survival outcomes in early-onset oesophageal adenocarcinoma patients: A systematic review and meta-analyses.World journal of gastroenterology · 2024Pooled it
- A Pilot Randomized Controlled Trial of Families Addressing Cancer Together for Parents With Cancer: Feasibility, Acceptability, and Preliminary Effects.Psycho-oncology · 2025Trial
- Oncofertility information interventions in patients with cancer: A systematic review and meta-analysis.Asia-Pacific journal of oncology nursing · 2026Review
- Cancer and dementia incidence are strongly correlated worldwide: evidence from cross-national regression analyses.Future science OA · 2026Article
- Nutrition and Cancer-From Prevention to After-Care.Nutrients · 2026Article
- Association of cancer characteristics with disability status and timing of onset among working-age cancer survivors.JNCI cancer spectrum · 2026Article
- Burden of early-onset laryngeal cancer in individuals aged 15-49 years: global, regional, and national estimates from the GBD 2021 study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Survival Outcomes in Early Onset Appendiceal Adenocarcinoma (EOAA).Annals of surgical oncology · 2026Article
- Early-onset gastrointestinal cancer patterns in Navarre: incidence, tumour features and patient survival outcomes.ESMO real world data and digital oncology · 2026Article
- Real-World Evidence of Disproportionate Financial Toxicity and Health-Related Social Needs Among Adolescents and Young Adults Receiving Care at an NCI-Designated Cancer Center.Current oncology (Toronto, Ont.) · 2026Observational
- Early-onset cancer in Latin America: incidence trends, evidence gaps and clinical implications.EClinicalMedicine · 2026Review
- Early-Onset Prostate Cancer: Epidemiology, Risk Factors, Biology, Clinical Features, Management, and Early Detection.MedComm · 2026Review
- Risk Prediction of Early-Onset Hepatocellular Carcinoma: Derivation and Validation in a Nationwide Young Adult Cohort.Alimentary pharmacology & therapeutics · 2026Article
- Deciphering the Molecular Basis: Integrative Multi-Method Analysis of Bioactive Constituents and Their Anti-Lung Cancer Mechanisms in Clinical Traditional Chinese Medicine Formulations.Chemistry & biodiversity · 2026Article
- Biological aging and generational shifts in early-onset cancer risk.Nature medicine · 2026Article
122 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to explore the global burden of early-onset cancer based on the Global Burden of Disease (GBD) 2019 study for 29 cancers worldwid. Methods and analysis: Incidence, deaths, disability-adjusted life years (DALYs) and risk factors for 29 early-onset cancer groups were obtained from GBD. Results: Global incidence of early-onset cancer increased by 79.1% and the number of early-onset cancer deaths increased by 27.7% between 1990 and 2019. Early-onset breast, tracheal, bronchus and lung, stomach and colorectal cancers showed the highest mortality and DALYs in 2019. Globally, the incidence rates of early-onset nasopharyngeal and prostate cancer showed the fastest increasing trend, whereas early-onset liver cancer showed the sharpest decrease. Early-onset colorectal cancers had high DALYs within the top five ranking for both men and women. High-middle and middle Sociodemographic Index (SDI) regions had the highest burden of early-onset cancer. The morbidity of early-onset cancer increased with the SDI, and the mortality rate decreased considerably when SDI increased from 0.7 to 1. The projections indicated that the global number of incidence and deaths of early-onset cancer would increase by 31% and 21% in 2030, respectively. Dietary risk factors (diet high in red meat, low in fruits, high in sodium and low in milk, etc), alcohol consumption and tobacco use are the main risk factors underlying early-onset cancers. Conclusion: Early-onset cancer morbidity continues to increase worldwide with notable variances in mortality and DALYs between areas, countries, sex and cancer types. Encouraging a healthy lifestyle could reduce early-onset cancer disease burden.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.