ArticleEnvironmental health perspectives2025
Impact of Maternal BPA Exposure during Pregnancy on Obesity in Male Offspring: A Mechanistic Mouse Study of Adipose-Derived Exosomal miRNA.
Article in Environmental health perspectives, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Characteristics of Exosomes and Microbiota in the Decidua of Patients With Early Pregnancy Loss and Their Impact on Trophoblast Cells.Molecular reproduction and development · 2026Article
- Maternal PMParticle and fibre toxicology · 2026Article
- Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe widespread use of bisphenol A (BPA) has led to universal exposure among the population, raising concerns about its health effects. Epidemiological studies have linked environmentally relevant levels of BPA exposure to obesity.
objectivesWe aimed to uncover the complex mechanisms by which oral exposure during pregnancy with BPA affects the offspring.
methodsWe conducted a two-stage mouse study. In stage 1, we gavaged dams with BPA at 0.05, 0.5, and
resultsGavage of DISCUSSION: The present study corroborates the regulatory function of adipose-derived exosomal miRNAs in obesity in male offspring mice resulting from BPA exposure during pregnancy. Exosomal miRNA may be a key and novel molecular biomarker in the adverse effects of chemical exposure during pregnancy. https://doi.org/10.1289/EHP14888.
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