ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2025
Longitudinal Association of Olfactory Function with Frailty in Older Adults: The Atherosclerosis Risk in Communities Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Dysfunction in Olfactory Identification and Physical Function Decline in Older Adults.JAMA otolaryngology-- head & neck surgery · 2026Article
- Olfaction and Coronary Heart Disease.JAMA otolaryngology-- head & neck surgery · 2026Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundEmerging evidence suggests that olfactory dysfunction may be a marker of frailty, a key predictor of adverse health outcomes in aging populations. This study examines the association between olfactory impairment and frailty in older adults.
methodsWe analyzed data from 5,231 participants (mean age: 75.3 ± 5.0 years; 59% women; 22% Black) of the Atherosclerosis Risk in Communities (ARIC) Study. Olfactory function, assessed using the 12-item Sniffin' Sticks Test at Visit 5 (2011-2013), was categorized as poor (0-8), moderate (9-10), or good (11-12). Frailty status was ascertained using both the Fried Frailty Phenotype and the Cumulative Frailty Index. Cross-sectional associations between olfactory function and frailty status were examined using logistic regression and linear regression. Logistic regression was used to examine the association between olfactory function and prefrailty or frailty occurring within five years among 1,519 participants robust at baseline.
resultsIn cross-sectional analyses, good olfactory function was associated with lower odds of frailty (odds ratio [OR] = 0.29, 95% confidence interval [CI]: 0.22, 0.39) and prefrailty (OR = 0.52, 95% CI: 0.45, 0.61). These associations remained robust after adjusting for covariates. Longitudinal analyses similarly showed a dose-response pattern, with improved olfaction associated with decreased odds of experiencing prefrailty (OR=0.63 95% CI [0.48, 0.83]) or frailty (OR=0.50, 95% CI [0.25, 1.02]).
conclusionsGood, as compared to poor, olfactory function is associated with lower frailty risk in older adults, suggesting that olfactory impairment may serve as an early marker of frailty. Further research is needed to elucidate the mechanisms linking olfaction and frailty and explore potential interventions.
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Registered trials
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