Evidence map›Paper›PMID 39886989›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2025

Investigating the role of adipose tissue in mobility and aging: design and methods of the Adipose Tissue ancillary to the Study of Muscle, Mobility, and Aging (SOMMA-AT).

Reichelle X Yeo, Theresa Mau, Zana M Ross, Nicholas P Edenhoffer, Jingfang Liu, Haley N Barnes, Li-Yung Lui, Joshua N Adkins, James A Sanford, Marcus M Seldin and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Reichelle X YeoAdventHealth Translational Research Institute, Orlando, Florida, USA.
Theresa MauDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0003-4278-6438
Zana M RossDepartment of Medicine, Division of Endocrinology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Nicholas P EdenhofferDepartment of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Jingfang LiuDepartment of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Haley N BarnesDepartment of Epidemiology, San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.
Li-Yung LuiDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Joshua N AdkinsBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.
James A SanfordBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.
Marcus M SeldinDepartment of Biological Chemistry, University of California, Irvine, Irvine, California, USA.ORCID 0000-0001-8026-4759
Carlos H ViesiDepartment of Biological Chemistry, University of California, Irvine, Irvine, California, USA.
Mingqi ZhouDepartment of Biological Chemistry, University of California, Irvine, Irvine, California, USA.
Heather L GregoryDepartment of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Frederico G S ToledoDepartment of Medicine, Division of Endocrinology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Maja Stefanovic-RacicDepartment of Medicine, Division of Endocrinology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Mary LylesDepartment of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Ashlee N WoodDepartment of Medicine, Division of Endocrinology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Polly E MattilaDepartment of Medicine, Division of Endocrinology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Elizabeth A BlakleyAdventHealth Translational Research Institute, Orlando, Florida, USA.
Iva MiljkovicDepartment of Medicine, Division of Endocrinology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-3155-9777
Peggy M CawthonDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0003-4938-9478
Anne B NewmanDepartment of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0002-0106-1150
Stephen B KritchevskyDepartment of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0003-3336-6781
Steven R CummingsDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Bret H GoodpasterAdventHealth Translational Research Institute, Orlando, Florida, USA.ORCID 0000-0003-1275-5147
Jamie N JusticeDepartment of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0003-2953-4404
Erin E KershawDepartment of Medicine, Division of Endocrinology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Lauren M SparksAdventHealth Translational Research Institute, Orlando, Florida, USA.

Funding

Study of Muscle, Mobility and Aging: SOMMA2R01AG059416 · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · 2025 to 2025
$15.0M
Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2002 to 2025
$7.7M
TECHNOLOGY COREP30AG024827 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2004 to 2025
$4.3M
National Center for Advancing Translational Science at Wake Forest UL1TR001420NCATS NIH HHS UL1 TR001420NIA Claude D. Pepper Older American Independence Centers at the University of Pittsburgh and Wake Forest University School of MedicineNIA NIH HHS P30 AG021332NIA NIH HHS P30 AG024827NIA NIH HHS R01 AG059416NIA NIH HHS R01 AG066474Study of Muscle, Mobility, and Aging R01AG059416Study of Muscle, Mobility, and Aging R01AG066474
6 · The paper itself

Abstract

backgroundAge-related changes in adipose tissue affect chronic medical diseases and mobility disability but mechanism remains poorly understood. The goal of this study is to define methods for phenotyping unique characteristics of adipose tissue from older adults.

methodsOlder adults enrolled in study of muscle, mobility, and aging selected for the adipose tissue ancillary (SOMMA-AT; N = 210, 52.38% women, 76.12 ± 4.37 years) were assessed for regional adiposity by whole-body magnetic resonance (AMRA) and underwent a needle-aspiration biopsy of abdominal subcutaneous adipose tissue (ASAT). ASAT biopsies were flash frozen, fixed, or processed for downstream applications and deposited at the biorepository. Biopsy yields, qualitative features, adipocyte sizes, and concentration of adipokines secreted in ASAT explant conditioned media were measured. Inter-measure Spearman correlations were determined.

resultsRegional, but not total, adiposity differed by sex: women had greater ASAT mass (8.20 ± 2.73 kg, p < .001) and biopsy yield (3.44 ± 1.81 g, p < .001) than men (ASAT = 5.95 ± 2.30 kg, biopsy = 2.30 ± 1.40 g). ASAT mass correlated with leptin (r = 0.54, p < .001) and not resistin (p = .248) and adiponectin (p = .353). Adipocyte area correlated with ASAT mass (r = 0.34, p < .001), BMI (r = 0.33, p < .001), adiponectin (r = -0.22, p = .005) and leptin (r = 0.18, p = .024) but not with resistin (p = .490).

conclusionIn addition to the detailed ASAT biopsy processing in this report, we found that adipocyte area correlated with ASAT mass, and both measures related to some key adipokines in the explant conditioned media. These results, methods, and biological repositories underscore the potential of this unique cohort to impact the understanding of aging adipose biology on disease, disability, and other aging tissues.

Indexed as

Adipose TissueAgingSubcutaneous Fat, AbdominalAdipocytesAdipokinesAdiponectinAdiposityAgedAged, 80 and overBiopsyFemaleHumansLeptinMagnetic Resonance ImagingMaleAdipokinesAdiponectinLeptinAdipokinesAdipose tissueHuman agingSOMMA

Identifiers

PMID39886989
PMCPMC12820589

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.