Evidence map›Paper›PMID 39887300›Full record

ArticleBiochemistry2025

Identifying Allosteric Hotspots in

Stephen P Dokas, Daniel K Taylor, Lydia L Good, Sanuja Mohanaraj, Rodrigo A Maillard

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Stephen P DokasDepartment of Chemistry, Georgetown University, Washington, District of Columbia 20057, United States.ORCID 0000-0002-9881-9510
Daniel K TaylorDepartment of Chemistry, Georgetown University, Washington, District of Columbia 20057, United States.
Lydia L GoodDepartment of Chemistry, Georgetown University, Washington, District of Columbia 20057, United States.
Sanuja MohanarajDepartment of Chemistry, Georgetown University, Washington, District of Columbia 20057, United States.
Rodrigo A MaillardDepartment of Chemistry, Georgetown University, Washington, District of Columbia 20057, United States.ORCID 0000-0001-5078-6775

Funding

Hierarchical Allosteric Regulation Mechanisms in Protein KinasesR15GM135866 · NIGMS · GEORGETOWN UNIVERSITY · PI MAILLARD, RODRIGO ALEJANDRO · 2019 to 2019
$451k
NIGMS NIH HHS R15 GM135866
6 · The paper itself

Abstract

Understanding the mechanisms of allosteric regulation in response to second messengers is crucial for advancing basic and applied research. This study focuses on the differential allosteric regulation by the ubiquitous signaling molecule, cAMP, in the cAMP receptor protein from

Indexed as

Bacterial ProteinsCyclic AMP Receptor ProteinEscherichia coli ProteinsMycobacterium tuberculosisAllosteric RegulationCyclic AMPEscherichia coliModels, MolecularProtein BindingStructural Homology, ProteinBacterial ProteinsCyclic AMPCyclic AMP Receptor ProteinEscherichia coli Proteins

Identifiers

PMID39887300
PMCPMC11840924

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.