ArticleMagnetic resonance in medicine2025
A straightforward approach for 3D single-shot arterial spin labeling-based brain perfusion imaging: Preventing artifacts due to signal fluctuations.
Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Next Generation 7 Tesla Arterial Spin Labeling With Rotated Spiral Acquisition Enables Mesoscale Resolution in 3D Brain Perfusion and Functional MRI.Magnetic resonance in medicine · 2026Article
- Rapid 3D whole-brain high-resolution TMagnetic resonance in medicine · 2026Article
- Velocity-Selective arterial spin labeling (VSASL) for cerebral blood volume assessment in gliomas: comparison with VSASL based cerebral blood flow and dynamic susceptibility contrast MRI.Neuroradiology · 2025Article
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4 authors.
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Abstract
purposeThe present work aims to evaluate the performance of three-dimensional (3D) single-shot stack-of-spirals turbo FLASH (SOS-TFL) acquisition for pseudo-continuous arterial spin labeling (PCASL) and velocity-selective ASL (VSASL)-based cerebral blood flow (CBF) mapping, as well as VSASL-based cerebral blood volume (CBV) mapping.
methodsDigital phantom simulations were conducted for both multishot echo planar imaging and spiral trajectories with intershot signal fluctuations. PCASL-derived CBF (PCASL-CBF), VSASL-derived CBF (VSASL-CBF), and CBV (VSASL-CBV) were all acquired using 3D multishot gradient and spin-echo and SOS-TFL acquisitions following background suppression. Both simulation and in vivo images were compared between multishot and single-shot compressed sensing-regularized sensitivity encoding (CS-SENSE) reconstructions.
resultsArtifacts were observed in both simulated multishot echo planar imaging and spiral readouts, as well as in in vivo multishot ASL perfusion images. A high correlation was found between the levels of signal fluctuations among interleaves and the severity of artifacts in both simulated and in vivo data. Image artifacts were more apparent in the inferior region of the brain, especially in CBF scans. These artifacts were effectively eliminated when single-shot CS-SENSE reconstruction was applied to the same data set.
conclusionASL images obtained from 3D segmented gradient and spin-echo or SOS-TFL acquisitions can exhibit artifacts caused by signal fluctuations among different shots, which persist even after the application of background suppression pulses. In contrast, these artifacts were prevented when single-shot CS-SENSE reconstruction was applied to the same SOS-TFL data set.
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