Evidence map›Paper›PMID 39887523›Full record

ArticleJournal of biochemical and molecular toxicology2025

Calcium Phosphate-Induced Injury in Kidney Tubular Cells-Supersaturated Solution vs Preformed Crystals.

Onyebuchi C Ukaeje, Sanjit K Roy, Samuel Shin, Sumiyya Raheem, Cory Reyes, Bidhan C Bandyopadhyay

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biochemical and molecular toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Onyebuchi C UkaejeCalcium Signaling Laboratory, Veterans Affairs Medical Center, Research Service, Washington, District of Columbia, USA.
Sanjit K RoyCalcium Signaling Laboratory, Veterans Affairs Medical Center, Research Service, Washington, District of Columbia, USA.
Samuel ShinCalcium Signaling Laboratory, Veterans Affairs Medical Center, Research Service, Washington, District of Columbia, USA.
Sumiyya RaheemCalcium Signaling Laboratory, Veterans Affairs Medical Center, Research Service, Washington, District of Columbia, USA.
Cory ReyesCalcium Signaling Laboratory, Veterans Affairs Medical Center, Research Service, Washington, District of Columbia, USA.
Bidhan C BandyopadhyayCalcium Signaling Laboratory, Veterans Affairs Medical Center, Research Service, Washington, District of Columbia, USA.ORCID http://orcid.org/0000-0003-2364-8945

Funding

Calcium transport in kidney proximal tubule and calcium phosphate stone formationR01DK102043 · NIDDK · INSTITUTE FOR CLINICAL RESEARCH, INC. · PI BANDYOPADHYAY, BIDHAN CHANDRA · 2015 to 2019
$1.1M
Mechanism of calcium phosphate stone formation in engineered 3D tubuleR21EB021483 · NIBIB · UNIV OF MARYLAND, COLLEGE PARK · PI NIE, ZHIHONG · 2016 to 2017
$385k
BCB also supported by VA Office of Research and Development, grant (I21BX006418-01A1).BLRD VA I01 BX006849BLRD VA I21 BX006418NIBIB NIH HHS R21 EB021483NIDDK NIH HHS R01 DK102043This study was supported in part by an R01 grant (# DK102043) from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to BCB and an R21 grant (# EB021483) from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) to BCB
6 · The paper itself

Abstract

Crystalline nephropathy (CN) is characterized by deposition of microcrystals within the kidney tubular microstructure, specifically in the renal tubular cells. Nephropathic conditions have been observed in kidney stone patients as nephrocalcinosis, resulting from the deposition of calcium phosphate (CaP) microcrystals mainly within the renal tubule. CaP microcrystals trigger nephrotoxicity and cell death leading to acute and chronic kidney disease and in some cases end stage renal disease. Although supersaturation of calcium (Ca

Indexed as

Calcium PhosphatesKidney TubulesAnimalsCell LineCell SurvivalCrystallizationEndoplasmic Reticulum StressMicecalcium phosphateCalcium Phosphatesapoptosiscalcium phosphate crystalscrystalline nephropathynecrosisoxidative stressproximal tubular cellssupersaturated solution

Identifiers

PMID39887523
PMCPMC12212628

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.