Evidence mapPaperPMID 39887975Full record

ReviewAmerican journal of physiology. Cell physiology2025

Body composition alterations in patients with lung cancer.

Deena B Snoke, Gary S Atwood, Emma R Bellefleur, Alice M Stokes, Michael J Toth

Abstract readReview
In one paragraph

Review in American journal of physiology. Cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Deena B SnokeDepartment of Medicine, University of Vermont College of Medicine, Burlington, Vermont, United States.ORCID 0000-0003-2189-9441
Gary S AtwoodDana Health Sciences Library, University of Vermont, Burlington, Vermont, United States.
Emma R BellefleurDepartment of Medicine, University of Vermont College of Medicine, Burlington, Vermont, United States.
Alice M StokesDana Health Sciences Library, University of Vermont, Burlington, Vermont, United States.
Michael J TothDepartment of Medicine, University of Vermont College of Medicine, Burlington, Vermont, United States.ORCID 0000-0003-0668-1911

Funding

Multidisciplinary Training in Lung BiologyT32HL076122 · NHLBI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI IRVIN, CHARLES G, POYNTER, MATTHEW E · 2004 to 2023
$6.1M
Skeletal Muscle Atrophy and Dysfunction in Human CancerR01AR065826 · NIAMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI TOTH, MICHAEL J · 2016 to 2021
$2.1M
Development of a clinically relevant mouse model of lung cancer cachexia to study pathoetiology and therapeutic strategiesR21CA283492 · NCI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI TOTH, MICHAEL J · 2023 to 2024
$392k
NCI NIH HHS R21 CA283492NHLBI NIH HHS T32 HL076122NIAMS NIH HHS R01 AR065826
6 · The paper itself

Abstract

Most patients with lung cancer experience cancer cachexia (CC), a syndrome of skeletal muscle and adipose tissue wasting. Knowledge of body composition changes in patients is limited, however, because most studies have been cross-sectional, comparing patients with noncancer controls or patients with and without CC. Few studies, in contrast, have evaluated body composition in patients with lung cancer over time. This review examines our current understanding of longitudinal body composition changes in patients with lung cancer and identifies modifying factors contributing to variation in muscle and adipose tissue wasting, focusing on biological sex. We identified 32 studies conducting longitudinal measurements of body composition by computed tomography, bioelectrical impedance, dual X-ray absorptiometry, or total body nitrogen, with a total of

Indexed as

Adipose TissueBody CompositionCachexiaLung NeoplasmsMuscle, SkeletalAdiposityFemaleHumansMaleadipositybiological sexcachexiamalignancymuscle wasting

Identifiers

PMID39887975
PMCPMC12199210

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.