Evidence map›Paper›PMID 39888354›Full record

ArticleAnnals of hematology2025

Molecular landscape of CD8

Yumei Liu, Mengyuan Liu, Xiaoman He, Liyan Yang, Mengying Zhang, Pu Tang, Limin Xing, Haiyue Niu, Huaquan Wang

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07031115 (Linperlisib in Acquired Pure Red Cell Aplasia), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07031115 phase2not yet recruitingnot on this map

Linperlisib in Acquired Pure Red Cell Aplasia: a Single-arm,Cphase II Prospective Clinical Study

TypeinterventionalSponsorPeking Union Medical College HospitalRan2025 to 2026Enrolled15ConditionsAcquired Pure Red Cell AplasiaArmsLinperlisib
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Favorable response to second-line sirolimus regardless ofTherapeutic advances in hematology · 2026
    Article
  3. Article
  4. Aberrant Hematopoiesis and CD8Thoracic cancer · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yumei Liu *Department of Hematology, Tianjin Medical University General Hospital, No. 154 Anshandao Road, Heping District, Tianjin, 300052, China.
Mengyuan Liu *Department of Hematology, Tianjin Medical University General Hospital, No. 154 Anshandao Road, Heping District, Tianjin, 300052, China.
Xiaoman He *Department of Hematology, Tianjin Medical University General Hospital, No. 154 Anshandao Road, Heping District, Tianjin, 300052, China.
Liyan YangDepartment of Hematology, Tianjin Medical University General Hospital, No. 154 Anshandao Road, Heping District, Tianjin, 300052, China.
Mengying ZhangDepartment of Hematology, Tianjin Medical University General Hospital, No. 154 Anshandao Road, Heping District, Tianjin, 300052, China.
Pu TangDepartment of Hematology, Tianjin Medical University General Hospital, No. 154 Anshandao Road, Heping District, Tianjin, 300052, China.
Limin XingDepartment of Hematology, Tianjin Medical University General Hospital, No. 154 Anshandao Road, Heping District, Tianjin, 300052, China.
Haiyue NiuDepartment of Hematology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China. niuhaiyue@tmu.edu.cn.
Huaquan WangDepartment of Hematology, Tianjin Medical University General Hospital, No. 154 Anshandao Road, Heping District, Tianjin, 300052, China. wanghuaquan@tmu.edu.cn.

Funding

Key Technology Research and Development Program of Tianjin China 18ZXDBSY00140National Natural Science Foundation of China 81170472National Natural Science Foundation of China 82400169Science and Technology Project of Tianjin Municipal Health Commission TJWJ2023QN006Scientific Research Project of Tianjin Municipal Education Commission 2022KJ235
6 · The paper itself

Abstract

The aberrant function of lymphocytes is considered a significant contributing factor to pure red cell aplasia (PRCA), but the precise mechanism by which T lymphocytes induce erythroid development stagnation remains unclear. In our study, the CD8

Indexed as

CD8-Positive T-LymphocytesRed-Cell Aplasia, PureAdultAgedFemaleHumansMaleMiddle AgedPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionSirolimusTOR Serine-Threonine KinasesMTOR protein, humanPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSirolimusTOR Serine-Threonine KinasesCD8Pure red cell aplasiaRNA sequencingT lymphocyte

Identifiers

PMID39888354
PMCPMC11971129

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.