Evidence map›Paper›PMID 39888835›Full record

ArticleMolecular pharmaceutics2025

Antiplatelet Effects of DMPC-Based Synthetic High-Density Lipoproteins: Exploring Particle Structure and Noncholesterol Efflux Mechanisms.

Antonela Rodriguez, Minzhi Yu, May Thazin Phoo, Michael Holinstat, Anna Schwendeman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Antonela RodriguezDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 428 Church St., Ann Arbor, Michigan 48109, United States.
Minzhi YuDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 428 Church St., Ann Arbor, Michigan 48109, United States.ORCID 0000-0002-3141-7285
May Thazin PhooDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 428 Church St., Ann Arbor, Michigan 48109, United States.
Michael HolinstatDepartment of Pharmacology, University of Michigan Medical School, 1150 W. Medical Center Dr., Room 2220D, Medical Sciences Research Building III, Ann Arbor, Michigan 48109, United States.
Anna SchwendemanDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 428 Church St., Ann Arbor, Michigan 48109, United States.ORCID 0000-0002-8023-8080

Funding

Development of phospholipid-based nanotherapeutics for treating abdominal aortic aneurysmR01HL165688 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Yanhong Guo, Anna Schwendeman · 2023 to 2026
$3.1M
12-HETrE regulation of blood coagulation, hemostasis, and thrombosisR35GM131835 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLINSTAT, MICHAEL ALLAN · 2019 to 2023
$2.3M
NHLBI NIH HHS R01 HL165688NIGMS NIH HHS R35 GM131835
6 · The paper itself

Abstract

Platelet activation is a key factor in the development of cardiovascular diseases. High-density lipoprotein (HDL) is known for its cardioprotective activities including antithrombotic actions. While HDL mimetics have been explored for their potential to regulate thrombosis, their influence on platelet activity remains unclear. This study explores the capacity of synthetic HDL (sHDL) to modulate platelet function and investigates the underlying mechanisms. We examined the effects of sHDL, formulated with various ApoA1 mimetic peptides (18A, 5A, and 22A) and full-length ApoA1 protein, all complexed with 1,2-dimyristoyl-

Indexed as

Blood PlateletsDimyristoylphosphatidylcholineLipoproteins, HDLPlatelet Aggregation InhibitorsApolipoprotein A-ICD36 AntigensCholesterolHumansPlatelet ActivationPlatelet AggregationApolipoprotein A-ICD36 AntigensCholesterolDimyristoylphosphatidylcholineLipoproteins, HDLPlatelet Aggregation InhibitorsapoA1 Mimetic peptidesCD36DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine)plateletssynthetic high-density lipoprotein (sHDL)thrombosis

Identifiers

PMID39888835
PMCPMC12321405

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.