Evidence map›Paper›PMID 39888945›Full record

ArticlePLoS pathogens2025

CD16 and CD57 expressing gamma delta T cells in acute HIV-1 infection are associated with the development of neutralization breadth.

Gina L Griffith, Kawthar Machmach, Ningbo Jian, Dohoon Kim, Margaret C Costanzo, Matthew Creegan, Isabella Swafford, Gautam Kundu, Lauren Yum, Jessica S Bolton and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS pathogens, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Gina L GriffithUS Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Kawthar MachmachUS Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Ningbo JianUS Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Dohoon KimUS Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Margaret C CostanzoUS Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Matthew CreeganUS Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Isabella SwaffordUS Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Gautam KunduUS Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Lauren YumUS Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Jessica S BoltonBiologics Research and Development, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Lauren SmithUS Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Bonnie M SlikeUS Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Elke S Bergmann-LeitnerBiologics Research and Development, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Rasmi ThomasUS Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Nelson L MichaelCenter for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Julie A AkeUS Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Leigh Anne EllerUS Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Merlin L RobbUS Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Samantha M TownsleyUS Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Shelly J KrebsUS Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Dominic Paquin-ProulxUS Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.ORCID https://orcid.org/0000-0003-1407-3414
RV217 Study Group

Funding

Evaluation of Antibody Responses Elicited by Zika Vaccination in Flavivirus-naïve and -experienced IndividualsR01AI155983 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI Vincent Dussupt · 2021 to 2026
$4.2M
NIAID NIH HHS R01 AI155983
6 · The paper itself

Abstract

New HIV vaccine approaches are focused on eliciting broadly neutralizing antibodies. We characterized early gamma-delta (γδ) T cell responses starting from pre-acquisition and during acute HIV infection (AHI) in participants previously characterized for neutralization breadth development. We found significant differences in γδ T cell surface marker expression in participants that developed neutralization breadth compared to those that did not. Activation of γδ T cells occurred within the first weeks of HIV acquisition and associated with viral load. Expression of CD16 on Vδ1 T cells and CD57 on Vδ2 T cells were found to be significantly higher in broad neutralizers during AHI, and associated with the development of neutralization breadth years later. In addition, the levels of CD16 on Vδ1 T cells was associated with early production of founder virus Env-specific IgM. Thus, γδ T cells may promote development of neutralization breadth, which has implications for HIV vaccine strategies.

Indexed as

Antibodies, NeutralizingCD57 AntigensHIV-1HIV AntibodiesHIV InfectionsIntraepithelial LymphocytesReceptors, Antigen, T-Cell, gamma-deltaReceptors, IgGAdultAIDS VaccinesFemaleGPI-Linked ProteinsHumansMaleAIDS VaccinesAntibodies, NeutralizingCD57 AntigensFCGR3B protein, humanGPI-Linked ProteinsHIV AntibodiesReceptors, Antigen, T-Cell, gamma-deltaReceptors, IgG

Identifiers

PMID39888945
PMCPMC11805418

What Socratic holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.